Anti-VZV IgG antibody and hs CRP levels correlate with progression of coronary artery atherosclerosis

سال انتشار: 1398
نوع سند: مقاله کنفرانسی
زبان: انگلیسی
مشاهده: 426

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شناسه ملی سند علمی:

ICCM13_073

تاریخ نمایه سازی: 25 آبان 1398

چکیده مقاله:

Background and Objectives: The relationship between high levels of anti-Varicella Zoster Virus (VZV) IgG antibody in cerebrospinal fluid (CSF) and cerebrovascular atherosclerosis commends a possible similar association in other vessels. We aimed to investigate the association of VZV-seropositivity with coronary artery atherosclerosis.Materials and Methods: We recruited 88 newly diagnosed patients with more than 50% stenosis in at least one of the main coronary arteries. As the control group, 99 age-matched individuals with normal/insignificant coronary artery findings were included. Clinical, paraclinical and demographical data were gathered at the time of sampling. High sensitivity (hs) CRP levels were measured by nephelometry. VZV-seropositivity was determined by measuring of anti-VZV IgG antibody level in plasma. Multivariable logistic regression was used to evaluate the correlation of data with coronary vascular atherosclerosis. Results: The frequency of VZV-seropositivity was significantly higher in the atherosclerosis group compared to the controls (OR=1.88; 95%CI=1.03-3.44). The plasma levels of anti-VZV IgG antibody were significantly higher in patients with atherosclerosis (Median=2.70, IQR=1.53-4.30 AU/mL) than in the controls (Median=2.10, IQR=1.70-3.10 AU/mL, p=0.034). HsCRP levels in patients and controls were 5.19±2.00 and 1.51±1.07 mg/L, respectively. A correlation between hsCRP and anti-VZV IgG antibody level in plasma was observed (r=0.40, p<0.001). The levels of hsCRP and anti-VZV IgG antibody increased based on the number of diseased vessels but only the difference in hsCRP levels reached a significant level (p<0.001 and p=0.168, respectively). Conclusion: Our data suggest that VZV-seropositivity and hsCRP elevation jointly increase the risk of atherosclerosis. Multifactorial nature of atherosclerosis, however, leaves more options for the inflammatory milieu to be generated.

نویسندگان

Hamed Fouladseresht

artment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Shahdad Khosropanah

Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Atefe Ghamar Talepoor

artment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

Shirin Farjadian

artment of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran