Protective effect of green tea extract on the deltamethrin-induced toxicity in mice testis: An experimental study
- سال انتشار: 1398
- محل انتشار: مجله طب تولید مثل ایران، دوره: 17، شماره: 5
- کد COI اختصاصی: JR_IJRM-17-5_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 352
نویسندگان
M.Sc., Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran- Student Research Committee, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
Ph.D., Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
Ph.D., Department of Anatomy, Faculty of Medicine, Molecular and Cell Biology Research Center, Mazandaran University of Medical Sciences, Sari, Iran
چکیده
Background: Deltamethrin (DM) is one of the environmental factors that can havedestructive effects on the male fertility. Green tea (GT) as a medicinal herb, hasantioxidant property.Objective: The present study investigated the protective role of GT extract in improvingthe harmful effects of DM on the testis.Materials and Methods: In this experimental study, 35 adult male mice (25–30 gr) weredivided in to five groups (n = 7/each). The control group received only normal saline.Sham received 0.2 ml corn oil. Green tea group received only GT of 150 mg/kg. bw;deltamethrin group received the DM at a dose of 0.6 mg/kg. bw; GT + DM received bothGT and DM. The effect of GT was assessed by measuring oxidative stress markers,sperm parameters, histological and immunohistochemical analysis.Results: The results showed that the count and motility of spermatozoa, testosterone,and Malondialdehyde significantly decreased (p < 0.001) and the abnormal spermatozoaincreased (p < 0.001) in DM group compared to control group. Moreover, enhancedcaspase-3expression and apoptosis were observed in DM-treated mice compared tocontrol group. Histologically, DM with a degenerative effect on testicular tissue reducedthe spermatogenesis progenitor cells. The epithelial height and the diameter of theseminiferous tubules were also reduced in the DM group. Treatment with GT in theDM-treated mice significantly improved these changes.Conclusion: With these findings, it was concluded that the GT treatment withantioxidant activity and anti-apoptotic property could protect the testicular injuryinduced by DM.کلیدواژه ها
Deltamethrin, Green tea, Oxidative stress, Testis, Caspase-3مقالات مرتبط جدید
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