Determination of the prevalence of cytomegalo virus, papilloma virus and herpes simplex virus in infertile men referring to IVF center, Afzalipour Hospital in Kerman in 2017
- سال انتشار: 1398
- محل انتشار: هشتمین کنگره بین المللی و جشنواره دانشجویی طب تولید مثل و سومین کنگره بین المللی ژنتیک تولید مثل
- کد COI اختصاصی: RMED08_068
- زبان مقاله: انگلیسی
- تعداد مشاهده: 386
نویسندگان
Department of Medical Microbiology, Kerman University of Medical Sciences, Kerman, Iran
چکیده
Background: Infertility is a major problem of modern medicine as it affects almost 20% of reproductive age couples. In 40-50% of cases, infertility is associated with men. Most male genital tract infections may induce infertility, Chronic viral infections can infect sperm and are one of the risk factors for male infertility. Viral infections can lead to male infertility by directly affecting the genital tract cells and indirect stimulating immunological responses. Herpes simplex virus, papilloma and cytomegalovirus can cause male genital tract infections without symptoms in a long period of time. There was no study on the prevalence of viral infections in infertile men and the association of male infertility with viral infections in Kerman province.Objective: We aimed to investigate the prevalence of viral infections (HCMV, HPV, and HSV1,2) in infertile men referred to the IVF Center, Afzalipour Hospital, in order to study correlation between infertility and viral infection in men.Materials and Methods: In a case-control study, at first, the samples were analyzed according to WHO guidelines. Then, based on the results of seminal fluid analysis, the samples were divided into two groups the case (100 samples) with an average age of 34.84 ± 5 and control group (100 samples) with an average age of 34.24±4.69, respectively. All samples were examined for the presence of HCMV DNA, HPV DNA, and HSV 1,2 DNA with Real Time PCR method. Data analysis was performed using SPSS version 19.Results: Based on the results of this study, the prevalence of HCMV infection in the seminal fluid of the case group was 23 (23%), which was significantly higher than the control group 7 (7%) (p=0.002). Also, the prevalence of HSV1.2 infection in infertile men was 4 (4%), which was significantly higher than fertile men (0) (p=0.04). There was no significant difference in the number of cases in the case and control groups in relation to the prevalence of HPV infection (p=0.52).Conclusion: According to our results, due to the high prevalence of HCMV and HSV1.2 infection in infertile men to fertile men there is a potential for a reduction in the count and motility of sperm and infertility caused by these viruses.کلیدواژه ها
IVF, HCMV, HSV 1, 2. HPV, Infertilityمقالات مرتبط جدید
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