Investigation of RKIP tumor suppressor gene expression in triple-negative breast cancer cells under microgravity conditions
- سال انتشار: 1397
- محل انتشار: بیستمین کنگره ملی و هشتمین کنگره بین‌المللی زیست‌شناسی ایران
- کد COI اختصاصی: BIOCONF20_236
- زبان مقاله: انگلیسی
- تعداد مشاهده: 330
نویسندگان
Space biology and Environment Center, Aerospace Research Institute,Ministry of Science, Research and Technology, Tehran, Iran
چکیده
Microgravity is considered to be the main source of space flight shock that affects cells and tissues and has an adverse effect on the health of astronauts. Changes in gravity as experienced by astronauts during space travel lead to changes in the physiology and even the morphology of the cells in the culture medium. In some studies, it has been observed that changes in gravity reduce the growth of some cancer cells and alter the expression of some genes and cellular functions. RKIP protein is a modulator of kinase activity and a cell balancing agent that also acts as a metastatic inhibitor in a variety of solid tumors, including breast cancer. RKIP expression in advanced tumors is reduced and its increase reduces the invasive potential of cancer cells without affecting their growth. In this study, we have cultivated triple-negative MDA-MB-231 breast cancer cell line on a clinostat device in order to the investigation of the RKIP gene expression changes under simulated microgravity conditions. Our results indicate that weightlessness changes the expression levels of RKIP gene. In general, our findings would have created a new light on the effects of microgravity on cell biology and human health.کلیدواژه ها
microgravity, RKIP protein, MDA-MB-231 cell lineمقالات مرتبط جدید
- Molecular Simulation of Water Transport through Polyamide Membrane in K+Cl- Salt Solution
- نانوکامپوزیت ها در دندانپزشکی
- Improving the characteristics of L-shaped graphene-based gas sensor using gold block on the surface
- Molecular Modelling of Gelatin Bundles for Atomistic Investigations Suggesting Two Stable Conformations
- بررسی تاثیر نانوذرات منیزیم بر جوانه زنی بذر و رشد گیاهچه بادرنجبویه Melissa officinalis
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.