Male factors: Do they have a role in recurrent pregnancy loss or In Vitro fertilization failure

  • سال انتشار: 1396
  • محل انتشار: سومین کنگره بین‌المللی تولیدمثل
  • کد COI اختصاصی: ISERB03_113
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 361
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نویسندگان

Zahra Yazdanpanahi

Faculty of Midwifery, School of Nursing and Midwifery, Shiraz University of Medical Sciences, Shiraz, Iran

Nehleh Parandavar

Faculty of Midwifery, School of Nursing and Allied Health, Jahrom University of Medical Sciences, Jahrom, Iran

Mina Taheri

School of Nursing and Midwifery, Shiraz University of Medical Science Fatemeh (PBUH) School of Nursing & Midwifery, Namazi Square, Shiraz, Iran

چکیده

Background: Recurrent pregnancy loss has defined as three or more consecutive pregnancy losses. It is estimated that about 10 to 15% of confirmed pregnancies result in recurrent pregnancy loss (RPL).The medical evaluation of RPL to date has focused mainly on the female. It would make sense that recurrent pregnancy loss and In Vitro Fertilization (IVF) failure may have a male factor since the male gamete contributes one-half of the genomic content to the embryo.This paper aimed to gain the current data regarding male factor contributions to RPL.Methods: A literature search was undertaken in March 2017,and included PubMed,Science Direct, CINAHL, and the Cochrane Library.Result: In male partner of the patients with recurrent pregnancy loss have a significant increase in sperm DNA fragmentation and decreased sperm functions. We have more recently seen that the chromosomes within the spermatoozoan itself can be altered over time due to paternal age, medicinal effects, radiation effects,or environmental effects. Increased sperm disomy or aneuploidy will also result in increased risk for miscarriages. Besides the genes,morphologic factors of the sperm may be associated with miscarriages: whether there is an increase in tapered forms or whether the sperm nuclei and chromatin condensations are abnormal.Certain cytokine abnormalities (MBP) and anything affecting the vascularity of the placenta from paternal genes are suggestive of a risk for miscarriage.Conclusion: Apart from routine semen analysis, sperm function tests may be an informative tool in cases of idiopathic recurrent pregnancy loss and IVF failure.Therefore, both the partners should be evaluated and treated simultaneously in order to achieve successful pregnancy.

کلیدواژه ها

Abortion, Pregnancy, Paternal age

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