Granulocyte colony-stimulating factor and reproductive medicine: A review

  • سال انتشار: 1394
  • محل انتشار: International Journal of Reproductive BioMedicine، دوره: 13، شماره: 4
  • کد COI اختصاصی: JR_IJRM-13-4_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 364
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نویسندگان

Marcelo Borges Cavalcante

Department of Gynecology and Obstetrics, University of Fortaleza, Fortaleza-CE, Brazil

Fabrício DA Silva Costa

Department of Perinatal Medicine, Pregnancy Research Centre, University of Melbourne, The Royal Women’s Hospital, Melbourne, Victoria, Australia. . Department of Obstetrics and Gynaecology, Pregnancy Research Centre, University of Melbourne, The Royal Wom

Ricardo Barini

Department of Obstetrics and Gynecology, State University of Campinas, Campinas-SP, Brazil

Edward Araujo Júnior

Department of Obstetrics,Paulista School of Medicine, São Paulo Federal University, São Paulo-SP, Brazil

چکیده

Background: Recently, the use of granulocyte colony-stimulating factor (G-CSF) has been proposed to improve pregnancy outcomes in reproductive medicine. Objective: A systematic review of the current use of G-CSF in patients who have difficulty conceiving and maintaining pregnancy was performed. Materials and Methods: Two electronic databases (PubMed/ Medline and Scopus) were searched. Study selection, data extraction and quality assessment were performed in duplicate. The subject codes used were granulocyte colony-stimulating factor, G-CSF, recurrent miscarriage, IVF failure, and endometrium. Results: The search of electronic databases resulted in 215 citations (PubMed/ Medline: 139 and Scopus: 76), of which 38 were present in both databases. Of the remaining 177 publications, seven studies were included in the present review. Conclusion: Treatment with G-CSF is a novel proposal for immune therapy in patients with recurrent miscarriage and implantation failure following cycles of IVF. However, a larger number of well-designed studies are required for this treatment to be established

کلیدواژه ها

Granulocyte colony-stimulating factor, Immunotherapy, Recurrent miscarriage, Reproductive medicine, Review

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