Effects of melatonin on histopathological changes after experimental ovarian torsion-detorsion in cat
- سال انتشار: 1386
- محل انتشار: مجله طب تولید مثل ایران، دوره: 5، شماره: 2
- کد COI اختصاصی: JR_IJRM-5-2_007
- زبان مقاله: انگلیسی
- تعداد مشاهده: 419
نویسندگان
Department of Obstetric and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Obstetric and Gynecology, Isfahan University of Medical Sciences, Isfahan, Iran.
Torabienejad Dental Research Center, Isfahan University.
چکیده
Background: During the detorsion of a torsioned ovary, oxidant agents are released and melatonin as an antioxidant can reduce ischemia. We studied the histopathological changes after using melatonin on experimental torsioned ovary in cat. Objective: The aim of this experimental study was to investigate the effects of Melatonin on histopathological changes in torsion – detorsion injury in cat ovary. Materials and Methods: An adnexal torsion – detorsion model was created by using 20adult cats randomly divided equally in to 2 groups of Saline and Melatonin. Ischemia was induced by iathrogenic 360° clockwise torsion of the cat adnex for 3 hr. Reperfusion was achieved for 3 hr. Melatonin or saline were injected intra peritoneally (10mg/kg) 30min before ovarian detorsion in both groups. After 3 hr of ovarian detorsion, ovarian tissue was removed and fixed in 10% formalin solution, embedded in paraffin andevaluated for ischemic indices. Results: Histological examination showed a significant improvement in ovarianmorphology in the melatonin treated cats. Edema and vasoconstriction in saline group were more severe than Melatonin group (p-value = 0.009). Hemorrhage and leukocyteinfiltration were also more obvious in saline group (p-value 0.0018) Conclusion: Our results demonstrated that Melatonin administration reduced ovarian histopathological damage due to oxidative injury associated with torsionکلیدواژه ها
Melatonin, Saline, Ischemia, Reperfusion, Catمقالات مرتبط جدید
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