Association of Nitric oxide levels and polycystic ovary syndrome (PCOS): A Systematic Review and Meta-Analysis

سال انتشار: 1401
محل انتشار: نهمین کنفرانس بین المللی یافته های نو در مامایی، زنان، زایمان و نازایی
کد COI اختصاصی: ICMWMI09_023
زبان مقاله: انگلیسی
تعداد مشاهده: 141

دانلود فایل این مقاله

نویسندگان

Seyed Sobhan Bahreiny

Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

Amir Hossein Mahdizade

Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mohammad Reza Dabbagh

Department of Biology, Faculty of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran.

Parisa safari foroushani

Department of Medical Genetics, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran

Mohammad Mehdi Abdi

Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran

چکیده

Introduction: Polycystic ovary syndrome (PCOS) is the most current endocrine disorder in women of childbearing age and the most common cause of infertility without ovulation that cannot be diagnosed with apparent symptoms. This study aimed to evaluate the biomarkers of oxidative stress including Nitric oxide (NO) for the diagnosis of PCOS. Methods: The keywords "oxidative stress," "polycystic ovary syndrome," and free radical products such as NO were searched in the PubMed, EMBASE, MEDLINE, Scopus, and Cochrane Library databases. All data were analyzed using Comprehensive Meta-Analysis V۳ software. Results: ۱۳ observational studies from ۱۹۹۵ to ۲۰۲۲ with a sample size of ۷۲۱ women were reviewed and showed that change Nitric oxide levels in women with PCOS. Result showed a significantly lower NO level (SMD= -۰.۵۹; ۹۵% CI, -۱.۱۵, -۰/۰۳; P= ۰.۰۰۰; I۲ > ۷۵%) in the PCOS group compared with the control. In addition, meta-regression showed that relationship was found between BMI and NO level (P= ۰.۰۲)Conclusion: Monitoring of specific free-radical product biomarkers such as NO might be beneficial to the diagnosis and prognosis of PCOS.

کلیدواژه ها

Nitric oxide; Polycystic ovary syndrome; Oxidative stress; Meta-analysis; Biomarkers.

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.