Genome-wide association study and gene ontology for growth and wool characteristics in Zandi sheep
- سال انتشار: 1399
- محل انتشار: دوفصلنامه علوم و فناوری دامداری، دوره: 8، شماره: 2
- کد COI اختصاصی: JR_KLST-8-2_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 215
نویسندگان
Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.
Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.
Department of Animal Sciences, University College of Agriculture and Natural Resources, University of Tehran, Karaj, Alborz, Iran.
Department of Animal Science, Faculty of Agricultural Sciences, University of Tabriz, Tabriz, East Azerbaijan, Iran.
Department of Animal Sciences, Faculty of Agriculture and Natural Resources, Arak University, Arak, Markazi, Iran.
چکیده
Genome-wide association studies (GWAS) is a major procedure for studying the genetics of complex economically important traits in sheep. The objective of this study was to determine the genomic regions affecting some growth traits and wool characteristics in Zandi sheep. This study is GWAS implementing a medium-density single nucleotide polymorphism (SNP) panel to determine the putative chromosome area affecting some growth and wool traits in a fat-tailed sheep breed, simultaneously. We used a selective genomic approach sampling DNA from animals at the extreme ends using the estimated breeding values derived from a total population size of over ۵,۰۰۰ animals. The examined phenotypic data included the birth weight, weaning weight, ۶, ۹, and ۱۲-months after birth weight, pre- and post-weaning average daily gain, fiber diameter (micron), prickle factor (%), staple length (mm), kemp (%) and medullated fiber. Genome-wide association analyses were performed based on the mixed linear model. Twenty-three regions, in which four were associated with more than one trait, located on ۱۲ chromosomeswere associated with the studied growth and wool traits (p < ۵×۱۰−۶). These genomic regions overlapping with KCNIP۴, PPARGC۱A, ASAP۱, ANK۲, WWOX, SYNE۱, FBXO۵, AKAP۶, FABP۳, ANGPTL۴, ATP۶V۱B۲, PARK۲, and KRTAP۱۱-۱ genes, were associated with postnatal growth, regulation of metabolic pathways, skeletal muscle differentiation, and bone growth. Gene ontology term enrichment analysis revealed that genes involved in positive regulation of muscle structure, and muscle tissue development were over-represented in the identified candidate genes.کلیدواژه ها
Candidate Gene, genome-wide association, Growth, sheep, woolاطلاعات بیشتر در مورد COI
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