The effect of calcium nanofluoride on breast cancer cell MDA-MB-۲۳۱ migration

  • سال انتشار: 1399
  • محل انتشار: بیست و یکمین کنگره ملی و نهمین کنگره بین المللی زیست شناسی ایران
  • کد COI اختصاصی: BIOCONF21_0700
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 241
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نویسندگان

Haniyeh Motie Arani

Department of Biochemistry and Biophysics, Faculty of advanced Sciences and technology, Islamic Azad University, Tehran Medical sciences, tehran, Iran

Saeed Hesami Tackallou

Department of Biology, Central Tehran Branch, Islamic Azad University, Tehran, Iran

Fereshteh Atabi

Department of Biochemistry and Biophysics, Faculty of advanced Sciences and technology, Islamic Azad University, Tehran Medical sciences, tehran, Iran

Hakimeh Zali

Assistant Professor School of Advanced Technologies in Medicine, shahid beheshti University of Medical Sciences, Tehran, Iran

چکیده

Cancer is abnormal cell proliferation. When cancer cells develop in the breast tissue, it is called breast cancer. Nanotechnology began at the suggestion of renowned physicist Richard Feynman. Nanotechnology has many advantages over conventional methods of cancer diagnosis, treatment and prevention. In this study, MDA-MB-۲۳۱ cancer cell migration was prevented by using calcium nanofluoride. Calcium nanofluoride was formed from the combination of calcium carbonate with synthesized hydrogen fluoride by sonication as nanoparticles. Verification of fabricated nanoparticles was performed using (TEM) and (DLS). Breast cancer cells were cultured in DMEM medium and by MTT assay on MDA-MB-۲۳۱ cell lines, cell viability was assessed and LC۵۰ calcium nanofluoride was obtained. Then, according to the obtained LC۵۰, cell migration test was performed on breast cancer cells. Finally, it was found that calcium nanofluoride reduced the migration of cancer cells by ۳۰%. Calcium fluoride nanoparticles have anti-cancer properties. More research is needed to confirm it as an anti-cancer agent.

کلیدواژه ها

Lymph nodes, Richard Feynman, MTT test, cell death, LC۵۰

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