Study of the effect of punicalagin on improving behavioral function in streptozotocin-induced Alzheimer's disease in male rats
- سال انتشار: 1399
- محل انتشار: بیست و یکمین کنگره ملی و نهمین کنگره بین المللی زیست شناسی ایران
- کد COI اختصاصی: BIOCONF21_0588
- زبان مقاله: انگلیسی
- تعداد مشاهده: 157
نویسندگان
Department of Biology, Faculty of Science, Bu-Ali Sina University, Hamadan, Iran
Department of Biology, Faculty of Science, Bu-Ali Sina University, Hamadan, Iran
Department of Physiology, Faculty of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
Mohammad Hossein Mohammadi Mahdiabadi Hasani
Neuroscience and Addiction Studies Department, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran
چکیده
Alzheimer's disease is a progressive and irreversible disease that eventually leads to neuronal loss and neurodegeneration. Based on the findings, oxidative stress is the most important hypothesis involved in the pathophysiology of Alzheimer's disease, in which free radicals lead to cell damage, pathology and memory loss. Punicalagin is the main antioxidant substance in pomegranate, and has many physiological activities, including strong antioxidant and anti-inflammatory properties. In this study, the protective effect of punicalagin against streptozotocin-induced memory impairment was investigated. Male Wistar rats weighing ۲۰۰-۲۵۰ g were used in five experimental groups. Streptozotocin was injected intracerebroventricularly into the animal (۳ mg/kg, twice with an interval of ۴۸ h). Also, Punicalagin was injected intracerebroventricularly (۰.۱ mg/kg) for ۳ days. ۱۴ days after receiving streptozotocin, behavioral tests for Novel object recognition and passive avoidance learning were performed to assess learning and memory ability, and then evaluated with Prism program. The results showed that the ability to Novel object recognition in the STZ group decreased significantly compared to the control group as well as the treatment group. Also, the study of the items measured in the passive avoidance learning test shows a decrease in learning of the STZ receiving group compared to the control and treatment groups. According to the results, it seems that punicalagin can prevent streptozotocin-induced learning and memory impairment and improve brain behavioral function. Therefore, considering the effectiveness of punicalagin in the results of behavioral tests to detect a Novel object recognition and passive avoidance learning, it can be used to reduce the destructive effects of Alzheimer's disease.کلیدواژه ها
Antioxidant, novel object recognition, passive avoidance learningمقالات مرتبط جدید
- Molecular Simulation of Water Transport through Polyamide Membrane in K+Cl- Salt Solution
- نانوکامپوزیت ها در دندانپزشکی
- Improving the characteristics of L-shaped graphene-based gas sensor using gold block on the surface
- Molecular Modelling of Gelatin Bundles for Atomistic Investigations Suggesting Two Stable Conformations
- بررسی تاثیر نانوذرات منیزیم بر جوانه زنی بذر و رشد گیاهچه بادرنجبویه Melissa officinalis
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.