ورود
مقالات فارسیISIکنفرانسهاژورنالها

Potential use of angiotensin receptor blockers in skin pathologies

محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 7
سال انتشار: 1402
نوع سند: مقاله ژورنالی
زبان: انگلیسی
مشاهده: 169

فایل این مقاله در 6 صفحه با فرمت PDF قابل دریافت می باشد

استخراج به نرم افزارهای پژوهشی:

لینک ثابت به این مقاله:
https://civilica.com/doc/1672013

شناسه ملی سند علمی:

JR_IJBMS-26-7_002

تاریخ نمایه سازی: 17 خرداد 1402

چکیده مقاله:

Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT۱R and AT۲R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT۱R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT۲R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-۶. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.

کلیدواژه ها:

Angiotensin II ، Cancer ، Keloid ، scar ، Skin disease ، Wound healing

نویسندگان

Keshvad Hedayatyanfard

Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Azadeh Khalili

Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Hosein Karim

Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran

Soren Nooraei

Student of School of Veterinary Medicine, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran

Ehsan Khosravi

Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran

Nazgol Sadat Haddadi

Department of Dermatology, University of Massachusetts School of Medicine, Worchester, MA, USA

Ahmad Reza Dehpour

Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

Gholamreza Bayat

Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

مراجع و منابع این مقاله:

لیست زیر مراجع و منابع استفاده شده در این مقاله را نمایش می دهد. این مراجع به صورت کاملا ماشینی و بر اساس هوش مصنوعی استخراج شده اند و لذا ممکن است دارای اشکالاتی باشند که به مرور زمان دقت استخراج این محتوا افزایش می یابد. مراجعی که مقالات مربوط به آنها در سیویلیکا نمایه شده و پیدا شده اند، به خود مقاله لینک شده اند :
  • Drosten M, Lechuga C, Barbacid MJO. Ras signaling is essential ...
  • Silva IMS, Assersen KB, Willadsen NN, Jepsen J, Artuc M, ...
  • Santos RAS, Oudit GY, Verano-Braga T, Canta G, Steckelings UM, ...
  • Hedayatyanfard K, Haddadi NS, Ziai SA, Karim H, Niazi F, ...
  • Ellis S, Lin EJ, Tartar DJCdr. Immunology of wound healing. ...
  • Hedayatyanfard K, Khoulenjani SB, Abdollahifar MA, Amani D, Habibi B, ...
  • Jadhav SS, Sharma N, Meeks CJ, Mordwinkin NM, Espinoza TB, ...
  • Rodgers K, Xiong S, Felix J, Roda N, Espinoza T, ...
  • Takeda H, Katagata Y, Hozumi Y, Kondo SJTAjop. Effects of ...
  • Yahata Y, Shirakata Y, Tokumaru S, Yang L, Dai X, ...
  • Sakai H, Matsuura K, Tanaka Y, Honda T, Nishida T, ...
  • Kamber M, Papalazarou V, Rouni G, Papageorgopoulou E, Papalois A, ...
  • Marin S, Godet I, Nidadavolu LS, Tian J, Dickinson LE, ...
  • Abadir P, Hosseini S, Faghih M, Ansari A, Lay F, ...
  • Hirt P, Lev‐Tov H. Use of topical valsartan as a ...
  • Nidadavolu LS, Stern D, Lin R, Wang Y, Li Y, ...
  • Mahdavian Delavary B, Van der Veer WM, Ferreira JA, Niessen ...
  • Rupérez Mn, Lorenzo Os, Blanco-Colio LM, Esteban V, Egido Js, ...
  • Liu W, Wang D, Cao YJCgt. TGF-β: A fibrotic factor ...
  • Niazi F, Hedayatyanfard K, Soroush M, Habibi B, Haddadi N-S, ...
  • Berman B, Maderal A, Raphael BJDS. Keloids and hypertrophic scars: ...
  • Niazi F, Hooshyar SH, Hedayatyanfard K, Ziai SA, Doroodgar F, ...
  • Gira AK, Brown LF, Washington CV, Cohen C, Arbiser JLJJotAAoD. ...
  • Ren M, Hao S, Yang C, Zhu P, Chen L, ...
  • Ulrich D, Ulrich F, Unglaub F, Piatkowski A, Pallua NJJoP, ...
  • Zhang T, Wang X-F, Wang Z-C, Lou D, Fang Q-Q, ...
  • Ogawa RJIjoms. Keloid and hypertrophic scars are the result of ...
  • Akershoek JJ, Vlig M, Brouwer K, Talhout W, Beelen RH, ...
  • Hedayatyanfard K, Ziai SA, Niazi F, Habibi I, Habibi B, ...
  • Zheng B, Fang Q-Q, Wang X-F, Shi B-H, Zhao W-Y, ...
  • Hu YY, Fang QQ, Wang XF, Zhao WY, Zheng B, ...
  • Murphy A, LeVatte T, Boudreau C, Midgen C, Gratzer P, ...
  • Kurt M, Akoz Saydam F, Bozkurt M, Serin M, Caglar ...
  • Rompe F, Artuc M, Hallberg A, Alterman M, Ströder K, ...
  • Tan WQ, Fang QQ, Shen XZ, Giani JF, Zhao TV, ...
  • Wang J, Chen L, Chen B, Meliton A, Liu SQ, ...
  • Min L-J, Cui T-X, Yahata Y, Yamasaki K, Shiuchi T, ...
  • Lin YT, Wang HC, Tsai MH, Su YY, Yang MY, ...
  • Herr D, Rodewald M, Fraser H, Hack G, Konrad R, ...
  • Munk VC, Sanchez de Miguel L, Petrimpol M, Butz N, ...
  • Christian JB, Lapane KL, Hume AL, Eaton CB, Weinstock MAJJotNCI. ...
  • Takeda H, Kondo SJTAjop. Differences between squamous cell carcinoma and ...
  • Moscarelli L, Zanazzi M, Mancini G, Rossi E, Caroti L, ...
  • Otake AH, Mattar AL, Freitas HC, Machado CML, Nonogaki S, ...
  • Ishikane S, Hosoda H, Nojiri T, Tokudome T, Mizutani T, ...
  • Egami K, Murohara T, Shimada T, Sasaki K-i, Shintani S, ...
  • Renziehausen A, Wang H, Rao B, Weir L, Nigro CL, ...
  • Nardone B, Majewski S, Kim AS, Kiguradze T, Martinez-Escala EM, ...
  • Wolf G, Ziyadeh FN, Thaiss F, Tomaszewski J, Caron RJ, ...
  • Zhao M, Bai M, Ding G, Zhang Y, Huang S, ...
  • Dandona P, Dhindsa S, Ghanim H, Chaudhuri AJJohh. Angiotensin II ...
  • Kaufman KM, Kelly J, Gray-McGuire C, Asundi N, Yu H, ...
  • Rahmati rm, saeidi m, eshghi gr. Serum angiotensin converting enzyme ...
  • Abdollahimajd F, Niknezhad N, Haghighatkhah HR, Namazi N, Niknejad N, ...
  • Huskić J, Mulabegović N, Alendar F, Ostojić L, Ostojić Z, ...
  • Song GG, Bae S-C, Kim J-H, Lee YHJJotr-a-as. The angiotensin-converting ...
  • Zeini MS, Haddadi N-S, Shayan M, Zeini MS, Kazemi K, ...
  • Madhur MS, Lob HE, McCann LA, Iwakura Y, Blinder Y, ...
  • Mehrotra P, Patel JB, Ivancic CM, Collett JA, Basile DPJKi. ...
  • Amisha PM, Pathania M, Rathaur VKJIJoIRiMS. Chronic plaque psoriasis exacerbated ...
  • Kawamura A, Ochiai TJEJoD. Candesartan cilexetil induced pustular psoriasis. Eur ...
  • Lamba G, Palaniswamy C, Singh T, Shah D, Lal S, ...
  • Vincent F, Bourke P, Morand EF, Mackay F, Bossingham DJIMJ. ...
  • Teplitsky V, Shoenfeld Y, Tanay AJL. The renin-angiotensin system in ...
  • Soto M, Delatorre N, Hurst C, Rodgers KEJFii. Targeting the ...
  • Inamadar ACJDT. Losartan as disease modulating therapy for recessive dystrophic ...
  • Nyström A, Thriene K, Mittapalli V, Kern JS, Kiritsi D, ...
  • Cappuccio G, Caiazza M, Roca A, Melis D, Iuliano A, ...
  • Kurosaka M, Suzuki T, Hosono K, Kamata Y, Fukamizu A, ...
  • Chisholm J, Gareau AJ, Byun S, Paletz JL, Tang D, ...
  • Trommer H, Neubert RJSp, physiology. Overcoming the stratum corneum: the ...
  • Trbojević JB, Odović J, Trbojević-Stanković J, Nešić DM, Jelić RJAoBS. ...
  • Israili ZJJohh. Clinical pharmacokinetics of angiotensin II (AT۱) receptor blockers ...
    • نمایش کامل مراجع