Keshvad Hedayatyanfard - Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
Azadeh Khalili - Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran
Hosein Karim - Cardiovascular Research Center, Alborz University of Medical Sciences, Karaj, Iran
Soren Nooraei - Student of School of Veterinary Medicine, Faculty of Veterinary Medicine, University of Shahrekord, Shahrekord, Iran
Ehsan Khosravi - Department of Veterinary Surgery, Science and Research Branch, Islamic Azad University, Tehran, Iran
Nazgol Sadat Haddadi - Department of Dermatology, University of Massachusetts School of Medicine, Worchester, MA, USA
Ahmad Reza Dehpour - Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
Gholamreza Bayat - Department of Physiology, Pharmacology and Medical Physic, School of Medicine, Alborz University of Medical Sciences, Karaj, Iran

Renin-angiotensin system (RAS) components such as angiotensin II, angiotensin receptors (AT۱R and AT۲R), and angiotensin-converting enzyme (ACE) are expressed in different cell types of the skin. Through AT۱R, angiotensin II increases proinflammatory cytokines contributing to fibrosis, angiogenesis, proliferation, and migration of immune cells to the skin. In contrast, AT۲R suppresses the effects mentioned above. Many studies show that angiotensin receptor blockers (ARBs) and angiotensin-converting enzymes (ACEi) reduce the proinflammatory cytokines and fibrogenic factors including transforming growth factor β (TGF-β), Connective tissue growth factor (CTGF), and IL-۶. This review article provides a detailed research study on the implications of ARBs in wound healing, hypertrophic scar, and keloids. We further discuss the therapeutic potentials of ARBs in autoimmune and autoinflammatory skin diseases and cancer, given their anti-fibrotic and anti-inflammatory effects.

Angiotensin II, Cancer, Keloid, scar, Skin disease, Wound healing