The effects of chrysin supplementation on Parkinson disease: current knowledge and future perspectives
- سال انتشار: 1398
- محل انتشار: دومین کنگره سالیانه کشوری دانشجویی طبری و بیست و دومین کنگره سالیانه کمیته تحقیقات دانشجویی دانشگاه علوم پزشکی مازندران
- کد COI اختصاصی: SRMMED22_253
- زبان مقاله: انگلیسی
- تعداد مشاهده: 533
نویسندگان
Student Research Committee, Kashan University of Medical Sciences, Kashan, I.R. Iran
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, I.R. Iran
چکیده
Background and Objective: Parkinson’s disease (PD) is a movement disorder that is related to loss of dopamine neurons in the substantia nigra. Different molecular pathways, including apoptosis, autophagy, inflammation and oxidative stress and aggregation of α-synuclein are involved in the pathophysiology of PD. Chrysin supplementation have an antioxidant and anti-inflammatory effects. Few studies reported effects of chrysin on PD. This review summarizes what is known regarding the effects of chrysin supplementation on PD and the mechanisms involved. Search Method: Databases including PubMed, MEDLINE, EMBASE and Web of Science were searched until February 31th, 2019. Findings: Animal studies reported that chrysin supplementation is benefit for PD. Chrysin decreased the oxidative stress, proteins related to apoptosis (Bax, and caspase 3) and inflammatory factors (tumor necrosis factor-α, interleukin-1β, interleukin-2, interleukin-6 and nuclear factor-kappa B). Also, chrysin supplementation significantly prevented decrease in dopamine neurons. Conclusion: Chrysin supplementation have beneficial effects in the treatment of PD. Clinical trials and more in vivo studies are required to evaluate the treatment effects of chrysin supplementation in the improvement of PD.کلیدواژه ها
Chrysin, Parkinson’s disease, Apoptosis, Oxidative stressمقالات مرتبط جدید
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