Use of aloe vera gel in regeneration of dental pulp and alveolar osteogenesis
- سال انتشار: 1398
- محل انتشار: دومین کنگره سالیانه کشوری دانشجویی طبری و بیست و دومین کنگره سالیانه کمیته تحقیقات دانشجویی دانشگاه علوم پزشکی مازندران
- کد COI اختصاصی: SRMMED22_051
- زبان مقاله: انگلیسی
- تعداد مشاهده: 323
نویسندگان
Dentistry student, Student Research Committee, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
چکیده
Background and Objective: Aloe vera gel has been consumed in the traditional medicine of many contries. many carbohydrate ingredients of aloe vera gel have been offered to be responsible for its activity . Acemannan is a important polysaccharide fraction which demonstrated to encourage the healing process such as proliferation of fibroblasts, synthesis of extracellular matrix and hard tissue healing. pulpal fibroblasts have been considered as the important cells for new alveolar bone and dentine formation .one of the important member of bone morphogenetic protein is BMP-2 . Thus this study shows effect of acemannan on regeneration dental pulp through BMP-2 expression in pulpal fibroblasts. Materials and Methods:This syudy is a narrative review article.the scholar was searched for any type of articles of effect of acemannan on pulp regeneration and PubMed(up to 2014) was searched for other articles and additional published papers about effect of aloe vera gel on regeneration of dental pulp. Findings: some studies show that acemnnan perfume well as pulp-capping agent in stimulating mineralized bridge formation in milk canine teeth . Many genes relevant to skeletal development and cell differentiation and growth were more strongly expressed by acemannan treatment . pulpal fibroblasts produce BMP-2 which is a certain growth factor for hard tissue formation and differentition . the impression of acemannan on BMP-2 mRNA levels in primary pulpal fibroblasts were shown by using RTPCR analysis. after treated with BMP-2 the bone marrow stromal cells, pulpal fibroblasts demonstrated differentiation and matrix protein secretion that cause to osteoinductive response. acemannan enhance proliferation of DDPC, growth factor and synthesis of extra cellular matrix, differention and mineralization in vitro and induces of mineralized bridge formation in inflamed pulp tissue in animal model .however acemannan is composed of repeating units of monosaccharide residues without Ca2+ to intiate calcium-phosphate compound formation or promote nucleation for calcification. Conclusion: modification of acemannan sponges may as well as increase the impression of acemannan in dentin regeneration. The impression of acemannanon dentin regeneration is comprarable with thah of MTA.use of acemannan which is less expensive compared with MTA . acemannan can be an alternative natural material for vital pulp therapy and avoids the extra cost .کلیدواژه ها
Acemnnan,traditional medicine, BMP-2, pulp regeneration , osteogenesisمقالات مرتبط جدید
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