Relationship Between Serum Interferon Gamma Level and CD8 and NK Immune Cells in women with Metastatic Breast Cancer in Urmia
- سال انتشار: 1398
- محل انتشار: پانزدهمین کنگره بین المللی زنان و مامایی ایران
- کد COI اختصاصی: COBGY15_221
- زبان مقاله: انگلیسی
- تعداد مشاهده: 517
نویسندگان
Master of Genetics-Young Researchers Club-Ardabil-Iran
Master of Genetics-Young Researchers Club-Ardabil-Iran
Master of Genetics-Young Researchers Club-Ardabil-Iran
چکیده
Breast cancer is the most common type of cancer among women worldwide. Interferon-gamma is a type of protein that host cells release in response to a pathogenic invasion that stimulates the immune system. NK cells are also part of the immune system s lymphocytes that target cancer-infected cells. Serum levels of interferon-gamma and CD8 and NK immune cells in women with metastatic breast cancer Materials and Methods: Our study population consisted of 5 patients with metastatic breast cancer and 5 women as control group. Serum levels of cytokines by ELISA and percentage of cells by flow cytometry using double antibodies Colors were determined against CD8 and CD3 / CD16 markers. The data were analyzed using SPSS V.24 and Anova test.Results: Serum levels of interferon-gamma in the patient group were equal to (0.24), which was significantly increased compared to the control group (P = 0.04) (CL = 1.19-3.71-OR = 95% Also CD4 lymphocyte percentage in blood Peripheral group of patients was equal to (0.22) which had a significant relationship with disease incidence (P = 0.05) (CL = 1.22-3.95-OR = 95%) but NK cell level was significantly different from group No control (P> 0.007).Conclusion: Based on the obtained results, interferon-gamma and CD8 cells have a significant relationship with the incidence of the disease, which can be used as prenatal factors.کلیدواژه ها
Breast Cancer - Polymorphism - Interferon Gamma - CD8 – NKمقالات مرتبط جدید
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