The Effects of PPAR-γ Agonist Pioglitazone on Hippocampal Cytokines, Brain-Derived Neurotrophic Factor, Memory Impairment, andOxidative Stress Status in Lipopolysaccharide- Treated Rats
- سال انتشار: 1398
- محل انتشار: سومین همایش بین المللی التهاب سیستم عصبی و سومین فستیوال دانشجویی علوم اعصاب
- کد COI اختصاصی: NIMED03_226
- زبان مقاله: انگلیسی
- تعداد مشاهده: 464
نویسندگان
Neuroscience Research Center, Department of Basic Sciences, Torbat Heydariyeh University of Medical Sciences, TorbatHeydariyeh, Iran
Psychiatry and Behavioral Sciences Research Center, Department of Neurocognitive Sciences, Mashhad University of Medical Sciences, Mashhad, Iran
Iranshahr University of Medical Sciences, Iranshahr, Iran
Department of Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
In the present study, the effects of pioglitazone on hippocampal cytokines, brain-derived neurotrophic factor (BDNF), oxidative stress status and memory in lipopolysaccharide (LPS) treated rats were investigated. Materials and Methods: The rats were divided into five groups (n=10 in each) :(1) control, (2) LPS (1 mg/kg, two hours before behavioral tests), (3-5) LPS-Pio 10 mg, LPS-Pio 20 mg and LPS-Pio 30 mg groups (10, 20 or 30 mg/kg pio 30 min before LPS). Finally, we removed brain tissue for biochemical measurements. Results: In LPS group, the escapelatency in Morris water maze test was longer while, the delay timeto enter the dark compartment in passive avoidance test were significantly shorter than in the control. Treatment by 20 and 30 mg of pioglitazone corrected these parameters. Malondialdehyde (MDA), nitric oxide metabolites, interleukin-6 (IL-6) and tumor necrosis factor-α (TNFα) concentration in the hippocampus of LPS group were higher than controlgroup while, in LPS-Pio20mg an LPS-Pio30mg group they were lower than LPS group. The thiol content, IL- 10 concentration and the activities of catalase (CAT) and superoxide dismutase (SOD) in hippocampal tissues of LPS group reduced compared to control group. Thesefactors enhanced in LPS-Pio20 mg and LPS-Pio30 mg groups compared to LPS. The hippocampal content of BDNF in LPS group was significantly lower compared to the control group. All treated groups had higher BDNF content in comparison to LPS group. Conclusion: Thefindings indicated that protective effects of pioglitazone against LPS-induced memory impairment were accompanied by decreasing of inflammatory cytokines, oxidative stress and increasing of BDNF.کلیدواژه ها
مقالات مرتبط جدید
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.