Anti-Proliferative Effect of Nano-Niosomal Formulation of Curcumin Against Glioblastoma Stem/Like Cells
- سال انتشار: 1398
- محل انتشار: سومین همایش بین المللی التهاب سیستم عصبی و سومین فستیوال دانشجویی علوم اعصاب
- کد COI اختصاصی: NIMED03_125
- زبان مقاله: انگلیسی
- تعداد مشاهده: 528
نویسندگان
Department of Medical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
The glioblastoma cancer stem cells (GSCs) can contribute to tumor initiation, recurrence and also resistance to current treatments. In the present study, curcumin was encapsulated in a noisome nanoparticle, termed niosomal-curcumin (N-CM). The aim of this study was to evaluate the anti-cancer effects of N-CM on GSCs in comparison with free curcumin (CM). Materials and Methods: The cancer stem cellswere isolated from the glioblastoma tumor tissue of a 50-year-old man. To evaluate cytotoxicity effects of N-CM, proliferation, viability, cell cycle, apoptosis, and ROS generation were assessed on GSCs. Results: N-CM significantly decreased cell viability in a dosedependentlymanner. N-CM treatment leads to higher accumulation of cells in the SubG1 phase (apoptotic) in comparison with CM. N-CM trigger apoptosis through the increasing Bax while decreasing Bcl2 expression. We also indicated an elevated amount of oxygen freeradicals, and a declined expression of NF-κB and IL-6, which may be explained cytotoxicity of N-CM against GSCs. Conclusion: These results introduce N-CM as a potent anti-tumor agent.کلیدواژه ها
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