Comparison the Effects of ZnO Nanoparticles and ZnO/Chitosan Nanocomposites on Diabetes-Induced Memory Impairment in Rats
- سال انتشار: 1397
- محل انتشار: بیست و ششمین سمینار شیمی آلی ایران
- کد COI اختصاصی: ISOC26_046
- زبان مقاله: انگلیسی
- تعداد مشاهده: 376
نویسندگان
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Department of Chemistry, Faculty of Science, University of Zabol, Zabol, Iran
Department of Basic Science, Faculty of Veterinary Medicine, University of Zabol, Zabol, Iran
چکیده
Among different nanomaterials, ZnO nanoparticles and ZnO/Chitosan nanocomposites possessa special status due to their own merits such as high specific surface area, optical transparency,bio-compatibility, non-toxicity, chemical and photochemical stability, convenientfabrication, high-electron communication features and electrochemical activities [1]. MeanwhileZnO nanoparticles have biological activity [2]. Chitosan a polysaccharide biopolymer[3], derived from naturally occurring chitin, is extensively being investigated in field of biomedicalmaterial and drug delivery [4]. In this project, ZnO nanoparticles and ZnO/Chitosannanocomposites were synthesized, and their effectiveness in preventing diabetes-inducedmemory loss and lipid peroxidation was evaluated. ZnO nanoparticles and ZnO/Chitosannanocomposites reversed diabetes-induced cognition insufficiency in passive avoidance learningand memory task (P < 0.05). The brain lipid peroxidation (P < 0.001) was lower in bothgroups compared to the untreated rats. Moreover, treatment with both nanoparticles prohibitedlearning and memory deficits of diabetic groups; however, there was no significant differencebetween the groups treated with ZnO/Chitosan nanocomposites or of ZnO nanoparticles.In conclusion, both ZnO nanoparticles and ZnO/Chitosan nanocomposites were effective inpreventing diabetes-induced memory loss and lipid peroxidation.کلیدواژه ها
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