Role of thermo-responsive polymers in cell sheet technology as a temporary scaffolds (review)
- سال انتشار: 1397
- محل انتشار: اولین کنگره بین المللی مهندسی بافت و پزشکی بازساختی ایران
- کد COI اختصاصی: ITERMED01_096
- زبان مقاله: انگلیسی
- تعداد مشاهده: 310
نویسندگان
Department of Tissue Engineering and Applied Cell Therapy, School of Advanced Technology in Medicine, Shahid Beheshti University of Medical Science, Tehran, Iran
Department of Tissue Engineering, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran
چکیده
Producing tick tissue in regenerative medicine is very difficult because of lack of oxygen and nutrient in bulk. Several methods and materials are investigating for thick tissue formation. Nearly all materials offer good possibilities and some limitations for tissue repair such as immunological responses for natural materials and less bioactivity and biocompatibility’ for synthetic materials. Overcoming these limitations, autologous cell sheet engineering using temporary scaffolds as synthetic extracellular matrix (ECM) is a new approach. Because it will be replaced by natural secreted one. It is an unique nanotechnology scaffold-free tissue reconstruction with clinical applications. This technology is based on thermo-responsive polymers such as poly N-isopropylacrylamide (PIPAAm).Using PIPAAm as a nonionic-polymer is beneficial not only for sheet harvesting but also for its integrity. At a temperature which is higher than the LCST of PIAPPAm, 32 C, surfaces are hydrophobic and suitable for cell adhesion. At temperatures lower than LCST, the surface becomes hydrophilic, inhibiting cell adhesion and making the detachable cell sheets. It is due to the hydrophobic isopropyl side groups that make the surface of PIPAAm capable of changing its cell adhesive properties as a function of temperature stimuli changes. This property can be modified using several molecules for enhancing the LCST point near physiologic temperature. Also using different nano-patterns or orientated of PIPAAm, and also grafting method, as a result of the polymer density, the thickness of a grafted thermo-responsive polymer layer play a role on how efficient a cell sheet is obtainedکلیدواژه ها
PIPAAm, Cell sheet, Thermo-responsiveمقالات مرتبط جدید
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