Improved some anticancer Platinum drugs delivery by mesoporous Silica microparticles application in chemotherapy

سال انتشار: 1397
محل انتشار: پانزدهمین همایش بیوشیمی فیزیک ایران
کد COI اختصاصی: CBC15_011
زبان مقاله: انگلیسی
تعداد مشاهده: 301

نویسندگان

Chemistry & Chemical Engineering Research Center of Iran, Tehran, Iran

چکیده

Oxali-platin, carboplatin and cisplatin are the clinical anti-cancer drugs based on platinum. To date, they accompanied with 5-fluorouracil is confirmed as first line chemotherapy for advanced colorectal cancer treatment. Since the cost of them is very high, the optimization method for its green synthesis is very important. Also, research shows drug nano-carriers could be refrained drug from undesired release before reaching tumor, and release drug in a controlled and smart manner. In this project, some Pt drugs with low solubility were synthesized and characterized for drug delivery. Then, the nano hallow sphere silica, MCM-41, was synthesized and fanctionalized by NH2 groups and characterized by applying XRD ،BET ،TGA ،FTIR، SEM. Drug release evaluation was done in vitro condition and micro dialysis memberane by UV and ICP methods. ICP results showed oxaliplatin is more loaded on MCM-41-NH2 than other platin drugs loaded. Due to immobilization of drugs on human serum albumun as bio carrier in blood, drug release from HSA-drug and MCM-41-NH2-drug were investigated and comparized. Data show that drugs releasing was slower in MCM-41-NH2-drug system than HSA-drug system and also this observation is more controllable for oxaliplatin drug that cause to less toxicity and side effect in chemotherapy.

کلیدواژه ها

Oxaliplatin, Anticancer drug, Cisplatin, Carboplatin, Drug delivery, Nano hallow sphere silica (NHSS), Nano-inorganic carrier, Human Serum Albumin

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