Comparison of Myricitrin and vitamin E on metabolic indexes, histology of the liver and pancreas of D-galactose induced mouse aging model.
- سال انتشار: 1397
- محل انتشار: پنجمین کنگره دانشجویی پژوهشی منطقه جنوب غرب کشور
- کد COI اختصاصی: SRCSRMED05_131
- زبان مقاله: انگلیسی
- تعداد مشاهده: 433
نویسندگان
Department of Physiology, Physiology Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Department of Physiology, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
Department of Anatomical Sciences, School of Medicine, Cell & Molecular Research Center, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Department of Physiology, Student Research Committee, Ahvaz Jundishapur University of Medical Science, Ahvaz, Iran
چکیده
Back ground and aim: Aging occurs during each person’s life, which varies from person to other person. The present study were evaluated the protective effects of hypoglycemia and pancreatic, myricitrin antioxidant in the d-galactose induce mouse model.Materials and methods: Seventy-two female adult mice (weighing 30–35 g) were randomly divided into six groups: control, D-galactose(Merck, Germany) 500 mg/kg/d for 45 days (subcutaneously injected), D-galactose+5, D-galactose+10, D-galactose+20 mg/kg/d Myricitrin(AvaChem San Antonio), D-galactose+100 mg/kg/d vitamin E for the last 28 days (by gavage).The fasting blood glucose, insulin level, and insulin-related biomarkers and lipid profile were measured.Results:Diabetes induced by D-galactose increases blood glucose levels (p< 0.001) and insulin secretion (p< 0.01). Myricitrin and Vitamin E has contributed to a greater increase in insulin secretion and decreased significantly blood glucose levels (p< 0.001) Myricitrin 10 and 20 mg / kg has an effect equivalent to Vitamin E in the secretion of insulin.HOMA-IR in the diabetic group has a significant increase (p< 0.001) that Myricitrin with the lowest concentration (p< 0.05) has reduced resistance to insulin. HOMA-β in the diabetic group has a significant decrease (p< 0.01) that on treatment with Myricitrin (p< 0.01) and Vitamin E (p< 0.001) has increased compared to the diabetic group.D-glucose a significant increase in TG (triglycerides) level, which Myricitrin (p< 0.001) and Vitamin E (p< 0.05) could reduce TG, but Myricitrin has a better effect on TG than in Vitamin E. Cholesterol has increased in the diabetic group, which Myricitrin and Vitamin E has been able to reduce cholesterol.LDL in the diabetic group has increased, which Myricitrin and Vitamin E has been able to reduce LDL (p< 0.05).Conclusion:Myricitrin improves the effects of d-galactose, including blood glucose level, insulin secretion, insulin resistance, and beta cell function.Key words: Aging, D-galactose, Myricitrinکلیدواژه ها
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