Trifluoromethylated Compounds: Synthesis and Evaluation of their Biological Activities

سال انتشار: 1397
محل انتشار: بیستمین کنگره شیمی ایران
کد COI اختصاصی: IRANCC20_812
زبان مقاله: انگلیسی
تعداد مشاهده: 259

نویسندگان

Department of Chemistry, Faculty of Science, Vali-e-Asr University of Rafsanjan, Rafsanjan ۷۷۱۷۶,Iran.

چکیده

Fluorine has come to be recognized as a key element in materials science.Furthermore, many fluorine-containing biologically active agents are finding applications as pharmaceuticals and agrochemicals. Heterocycles containing only one trifluoromethyl group directly attached to the ring (trifluoromethylated heterocycles) constitute an extended family of organic compounds with substantial potential for application, most notably in biomedical and agricultural fields [1]. One of common methods for introducing the trifluoromethyl group into organic compounds is the use of building blocks containing CF3 group such as trifuoroacetimidoyl chloride. Trifuoroacetimidoyl chloride are obtained via refluxing a mixture of trifluroacetic acid and a primary amine in carbon tetrachloride in the presence of triethylamine and triphenylphosphine [2]. In this study a new series of trifluoromethylated compounds have been synthesized using trifuoroacetimidoyl chloride [3]. Also we assessed biological activity of some new synthesized compounds. These compounds displayed good to excellent biological activities such as antimicrobial, antibacterial and anticancer. [4]

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