4H-benzochromene derivatives catalyzed by KCC-1@SO3H nano heterogeneous solid acid

سال انتشار: 1397
محل انتشار: بیستمین کنگره شیمی ایران
کد COI اختصاصی: IRANCC20_703
زبان مقاله: انگلیسی
تعداد مشاهده: 510

نویسندگان

Department of Chemistry, Faculty of Science, University of Birjand, Birjand, Iran.

چکیده

During the last decade, 4H-benzochromene derivatives have received great attention in organic chemistry due to their biological and pharmaceutical properties such asantimicrobial, antiviral, sex pheromone, antitumor, anti-inflammatory, anti-tubercular, and cancer therapy [1]. These compounds were synthesized via multicomponentreaction of aromatic aldehyde with malononitrile and β-naphthol in the presence of various Bronsted and Lewis acids such as methane sulphonic acid, TiCl4, H14 [NaP5W30O110], p-TSA, as well as basic catalysts such as g-alumina, Na2CO3, K2CO3, piperidine, nano sized MgO and NaOH. To overcome some drawbacks like the recovery of catalysts and promote the catalytic efficiency, Bronsted acids are supported on solid material producing heterogeneous solid acid. A KCC-1 silica nanosphere with high surface area, which comes from its fibrous morphology, is an excellent nominee to utilize as a support to design efficient heterogeneous nanocatalysts that would satisfy these conditions [3]. In this study, 4Hbenzochromene derivatives were synthesized by multicomponent reaction of aromatic aldehyde with malononitrile and β-naphthol in the presence KCC-1@SO3H in water media at reflux conditions. The results showed that the corresponding products were obtained in excellent yields (90-95%)(fig. 1). The catalyst was reused for several times without lack of activity.

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