Electrochemical investigation of acetaminophen/amlodipine interactions

  • سال انتشار: 1397
  • محل انتشار: بیستمین کنگره شیمی ایران
  • کد COI اختصاصی: IRANCC20_393
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 354
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نویسندگان

Fahime Tavakoli

Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran

Hassan Shayani-Jam

Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran

Mohammad Reza Yaftian

Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran

Masoumeh Parinejad

Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, Iran

چکیده

In this research, electrochemical oxidation of acetaminophen was investigated in the presence of amlodipine, an amine-containing drug. The electrochemical techniquesused include cyclic voltammetry and controlled-potential coulometry. The results indicated that N-acetyl-p-benzoquinone-imine (NAPQI) produced from electrooxidation of acetaminophen can react with amlodipine, based on the Michael addition reaction [1,2]. Corresponding product was synthesized in aqueous solutions by means of electrosynthesis, using a carbon electrode in an undivided cell. It was an environmentally friendly method because in which the application of toxic reagents has been eliminated. Synthesized product was identified by FT-IR, 1H-NMR and 13CNMR spectroscopies. The cyclic voltammograms were analyzed by digital simulation to measure thehomogeneous parameters for the suggested electrode mechanism [3]. The observed rate constant (kobs) for the reaction of electrochemically generated N-acetyl-p benzoquinn-imine with amlodipine were calculated in various pH (e.g. kobs=652±32.6 (M-1s-1)).

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