DIETARY FAT INTAKE AND RISK OF OVARIAN CANCER: A SYSTEMATIC REVIEW AND DOSE-RESPONSE META-ANALYSIS OF OBSERVATIONAL STUDIES

سال انتشار: 1397
محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
کد COI اختصاصی: INC15_523
زبان مقاله: انگلیسی
تعداد مشاهده: 441

نویسندگان

Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences (TUMS), Tehran, Iran

چکیده

Background and Aim: Observational studies have reported controversial evidence of the association between dietary fat intake and ovarian cancer. This dose-response meta-analysis aimed to clarify quantitatively the association between dietary fat intake and ovarian cancer.Methods: We searched the PubMed, Scopus and ISI Web of Science databases up to November 2017. Risk ratios (RRs) and 95% confidence intervals (95% CI) were calculated using a fixed effects model for highest versus lowest intake categories. The linear and non-linear relationships between fat intake and risk of ovarian cancer were investigated. Heterogeneity, sensitivity analysis and publication bias were also assessed.Results: Overall, 21 studies (9 cohort and 12 case-control studies) involved approximately 900,000 subjects were included. A significant nonlinear association was found between total fat intake with the risk of ovarian cancer, with a relatively steep slope at total fat intake higher than 30 g/day (p non-linearity< 0.01). Moreover, the risk of ovarian cancer was increased in non-linear form for both saturated and monounsaturated fat from 25g/day (p non-linearity< 0.05). According to the findings from linear meta-analysis, we observed a 2, 2, 1 and 1% greater risk of ovarian cancer per 10, 0.5, 2.5g/day and 50mg/day increase in total, trans and monounsaturated fat intake as well as cholesterol, respectively. However, this association for monounsaturated fat (p=) and cholesterol (p=) was marginally significant. Conclusion: The findings of this meta-analysis suggest that dietary total, trans, saturated and partially monounsaturated fat as well as cholesterol intake is positively associated with increased risk of ovarian cancer.

کلیدواژه ها

Meta-analysis, Dose response, Ovarian cancer, Dietary fat

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