PROTECTIVE EFFECTS OF SPIRULINA PLATENSIS AND HONEY ON ACETIC ACID-INDUCED ULCERATIVE COLITIS IN RATS

  • سال انتشار: 1397
  • محل انتشار: سومین کنگره بین المللی و پانزدهمین کنگره تغذیه ایران
  • کد COI اختصاصی: INC15_515
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 426
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نویسندگان

Nadia Rezaei

School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

Mohammad Hassan Eftekhari

School of Nutrition and Food Sciences, Shiraz University of Medical Sciences, Shiraz, Iran

Nader Tanideh

Stem cells technology research center Shiraz University of Medical Sciences, Shiraz, Iran

Maral Mokhtari

Department of Pathology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran

چکیده

Background and Aim: In this study, we examined and compared the protective effects of SP and honey on ulcerative colitis induced by acetic acid (AA) in rats. Methods: A total of 40 male rats were allocated into 5 groups (n=8) and received pretreatment for 32 consecutive days. Group 1 (control) was administered normal saline, group 2 (AA-colitis group) received normal saline plus AA, group 3 received 1 ml of honey/day, group 4 received 1 ml of honey/day plus 1 g/kg of SP, and group 5 was administered 1 g/kg of SP. Colitis was induced on the 30th day in groups 2 to 5. On day 32, clinical activity was determined, and anaesthetized animals were sacrificed. Serum interleukin-6 (IL-6), IL-1β, tumor necrosis factor-α (TNF-α), glutathione peroxidase (GPx), reduced glutathione (GSH), total antioxidant capacity (TAC), superoxide dismutase (SOD), myeloperoxidase (MPO) in colonic tissues, prostaglandin E2 (PGE2), malondialdehyde (MDA), nitric oxide (NO), and colonic weight/length ratio were determined. In addition, histopathological changes of the colon were observed microscopically. Results: Pretreatment with honey, SP, and combination regimen significantly attenuated IL-6, TNF- , IL-1 , MPO, PGE2, NO, and MDA levels and increased SOD, GSH, GPx, and TAC levels. Conclusion: Honey and SP may be favorable foods in preventing oxidative stress and inflammatory diseases such as ulcerative colitis.

کلیدواژه ها

Honey; Spirulina platensis; Ulcerative colitis; Inflammation; Oxidative stress, Antioxidant

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