Toxigenic Clostridium difficilein Hospitalized Patients
- سال انتشار: 1397
- محل انتشار: دوازدهمین کنگره بین المللی میکروب شناسی بالینی ایران
- کد COI اختصاصی: ICCM12_063
- زبان مقاله: انگلیسی
- تعداد مشاهده: 431
نویسندگان
Microbiology Department, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
Microbiology Department, School of Medicine, Gonabad University of Medical Sciences, Gonabad, Iran
Student Research Committee, Gonabad University of Medical Sciences, Gonabad, Iran
چکیده
Background and Objectives: Clostridium difficile is one of the most common nosocomial bacteria in the industrial nations and the main etiological agent of antibiotic-associated diarrhea and pseudomembranous colitis. Most people that develop disease symptoms have undergone antibiotic treatment. Diarrhoea illnesses are a relatively frequent side effect of antibiotic therapies.The aim of this study was to assess the detection of pathogenic toxin A/B-positive Clostridium difficilestrains among hospitalized patients with diarrhoea in Gonabad, Iran.Materials and methods: In this research hospitalized patients submitted to 22Bahman hospital (Gonabad, Iran) and if they had a liquid stool specimen were included. A total of 50 consecutive unformed or liquid feces samples from hospitalized patients were obtained for inclusion in this study. Stool samples were collected and Clostridium difficile toxin A/B immunoassay was performed according to manufacturer guidelines.Results: In present study, total 50 patients with liquid stool sent for Clostridium difficile toxin A/B assay were enrolled in the study. Patients consisted of 18 males (36%) and 32 females (64%). Maximum number of cases were in the age group of less than 10 years (n=29, 58%). Among the studied patients, 16 (32%) cases were positive for Clostridium difficile toxin A/Bby immunochromatographic assay. Analysis of data revealed that frothy-four (88%) patients received on or more antibiotic treatment on admission and hospitalization (17 patients: ceftriaxone, 3 patients: metronidazol, 3 patients ciprofloxacin, 3 patients: ceftriaxone + metronodazol).Conclusion: Diagnostic of pathogenic Clostridium difficile can improve the handling of infection and may lead to a more reasonable use of antibiotics, as the physician will rapidly obtain the clinical microbiology results. As a result, we need to refocus our prevention and management protocols.کلیدواژه ها
DiarrheaToxigenic Clostridium difficile, Hospitalized patients, Stool antigenمقالات مرتبط جدید
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