The ROMA (Risk of Ovarian Malignancy Algorithm) for estimating the risk of epithelial ovarian cancer in women (presentation of new studies)

سال انتشار: 1396
محل انتشار: نوزدهمین همایش سالانه و دومین همایش بین المللی آسیب شناسی و طب آزمایشگاه
کد COI اختصاصی: ACPLMED19_082
زبان مقاله: انگلیسی
تعداد مشاهده: 374

نویسندگان

pathology lab, Atieh hospital, tehran, Iran

چکیده

Introduction: Ovarian cancer is one of the three most common malignant tumors in the female reproductive system. In approximately, 70% of all cases of ovarian cancer, the disease is not diagnosed before reaching an advanced stage. The early diagnosis of ovarian malignant tumor becomes a key factor in improving the survival rate of patients. Tools currently in use for differentiating between low- and high-risk patients with ovarian cancer are the tumor markers carbohydrate antigen-125 (CA- 125) and the human epididymis protein 4 (HE4), as well as the index value of risk of ovarian malignancy algorithm (ROMA). The ROMA index value is an algorithm that takes into account the levels of CA-125 and HE4 together with menopausal status using quantitative and objective parameters. Premenopausal women with a ROMA value ≥11.4, had a higher risk of ovarian cancer. Postmenopausal women with ROMA value ≥29.9 had a higher risk of ovarian cancer. Materials and Methods: A total of 64 patients in the ovarian cancer group were selected, which was examined and confirmed by postoperative pathological findings. There were 14 cases of papillary serous cystadenocarcinoma, 1 case of clear cell carcinoma, 7 cases of mucinous cystadenocarcinoma and 42 cases of serous cystadenocarcinoma. Samples were collected from all the patients prior to surgery and 3 ml blood was collected. Serum was centrifuged at 2000 × g and stored at −20 and −80°C until use. Serum CA-125 and HE4 were detected using the full automatic hemiluminescenceanalyzer Cobs e411 and the corresponding kit according to manufacturer s protocol .Briefly, serum HE4 and CA-125 levels were calculated for ROMA index value using the Roche ROMA index of ovarian cancer risk assessment software. Serum HE4 and CA-125 reference range was < 140 pmol/l and < 35 U/ml, respectively. Result: The ROMA index demonstrated the highest sensitivity and negative predictive value for ovarian cancer. HE4 had the highest specificity and positive predictive value. The specificity of HE4 for ovarian cancer was higher in the postmenopausal women, as reported elsewhere. The sensitivity, specificity, positive predictive value and negative predictive value of the ROMA index in ovarian cancer were the highest (91.89, 96.97, 97.14 and 91.45%), respectively.Conclusion: In conclusion, application of the ROMA index and HE4 for the diagnosis of ovarian cancer was found to be effective and it has good clinical application value, which may be useful for clinicians

کلیدواژه ها

CA 125.HE-4. roma, Ovarian cancer

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