Diazinon-Induced Ovarian Toxicity and Protection by Vitamins E
- سال انتشار: 1394
- محل انتشار: هفدهمین همایش سالانه آسیب شناسی و طب آزمایشگاه
- کد COI اختصاصی: ACPLMED17_008
- زبان مقاله: انگلیسی
- تعداد مشاهده: 517
نویسندگان
Lecturer, Department of Basic Sciences, Torbat Heydariyeh University of Medical sciences, TorbatHeydariyeh, Iran
Professor, Department of Anatomy and cell biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
Assistant professor , Department of Pharmacology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
MSc , Department of Anatomy and cell biology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
چکیده
Background:DZN (diazinon) is an organophosphate insecticide that had been used in agriculture and for domestic and veterinary use for several years and caused many negative effects on plants and animal species, especially on human. The aim of present study was to evaluate the effects of DZN on MDA (malondialdehyde) and GSH (glutathione) levels in female rat reproductive tissue (ovary) and to assess the protective role of vitamin E. Methods: A total of 30 adult female Wistar rats were divided into five groups: control group (without any intervention), sham group (received only pure corn oil, as solvent), experimental group 1 (DZN+corn oil, 60 mg/kg), experimental group 2 (vitamin E, 200 mg/kg), and experimental group 3 (DZN+vitamin E, the same dosage). All drugs were injected intraperitoneally, except vitamin E which was administrated by gavage. The animals were scarified after two weeks and MDA as a marker of lipid peroxidation and GSH content were measured in ovarian tissue.Results:DZN reduced GSH content and increased MDA level in ovary compared with the control group (P< 0.001). Vitamin E plus DZN increased GSH content but decreased DZNinducedMDA elevation in rat ovarian tissue . Conclusion: Oxidative stress contributes to DZN-induced ovarian toxicity. The results of this study suggested that vitamin E may have a protective effect on DZN-induced ovarian toxicity. Oxidative stress contributes to DZN-induced ovarian toxicity. The results of this.کلیدواژه ها
Diazinon, Glutathione, Malondialdehyde, Ovary, Vitamin Eمقالات مرتبط جدید
- Effect of Salicylic Acid and Root Inoculation with P. indica on Cd Phytoremediation Efficiency and Degradation of Soil Fuel Oil in the Salinity Stress
- Acute Effect of Concurrent Exercise on Serum Leptin and Resistance Insulin Response in Sedentary Men
- Analysis of Incidents Recorded Data of in Kashan Fire Department During ۱۹۹۹-۲۰۱۶
- Development and Psychometric of “Public Awareness on Emergency Response in the Workplace Questionnaire”
- تجزیه و تحلیل علل ریشه ای حوادث شغلی در صنایع به کمک تکنیک های مرسوم بررسی حوادث مطالعه موردی یک حادثه منجر به فوت در پست ۲۳۰ کیلوولت
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.