ANTIBACTERIAL AND ANTICANCER ACTIVITY OF A BIOFLAVONOID FRACTIONATED FROM ALLIUM ASCALONICUM
- سال انتشار: 1397
- محل انتشار: نوزدهمین کنگره بین المللی میکروب شناسی ایران
- کد COI اختصاصی: MEDISM19_453
- زبان مقاله: انگلیسی
- تعداد مشاهده: 506
نویسندگان
Department of Food and Drug Control, Faculty of Pharmacy, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran
Department of Microbiology, Infection and Tropical Diseases Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
Department of Microbiology, Infection and Tropical Diseases Research Center, School of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IR Iran
چکیده
Background and Aim: Shallots are an important part of the diet of many populations and there is long-held belief in their health enhancing properties. Shallot extract prevent the proliferation of cancer cells and has anti-bacterial properties. The objective of this study was the evaluation of antibacterial and anticancer activity bioflavonoid fractionated from Allium ascalonicum against some bacteria and cancer cells by MIC and MTT methods.Methods: The effect of cytotoxic extracts using MTT colorimetric assay was performed. Doxorubicin was used as a positive control sample and medium containing 5% DMSO as a negative control in cell-free extracts will be considered. Plates incubated for 48 hours in CO2 5% and then at 37 ° C. 100 ml solution of DMSO to dissolve the formazan crystals replace the previous solution and absorption at a wave length of 560 nm is read by Elisa reader. Also the effect of antibacterial extract was evaluated by MIC method.Results: Allium ascalonicum showed antifungal and anticancer activity. C.diphtheriae was most sensitive, P. aeruginosa and S. pyogens were most resistant bacteria tested. In our study the effect of shallot extract was a dose-dependent pattern and the highest sensitivity cells was observed after 72 hours.Conclusion: It is of interest that the extract of this plant has shown much less cytotoxicity against the normal cell line. The results of our study indicated that A. ascalonicum can be a candidate for treatment of many diseases.کلیدواژه ها
Laboratory examination, Antimicrobial effect, Anti-cancer cells, Shallot plant extractاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.