Analysis of two allelic HLA haplotypes in different ethnicities of Khuzestan Province
- سال انتشار: 1396
- محل انتشار: دومین کنگره بین المللی و دهمین همایش ملی نوروژنتیک ایران
- کد COI اختصاصی: NGCMED10_047
- زبان مقاله: انگلیسی
- تعداد مشاهده: 563
نویسندگان
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
Department of Genetics, Faculty of Sciences, Shahid Chamran University of Ahvaz, Ahvaz, Iran
چکیده
Introduction: There is accumulating evidence that the HLA gene variants are associated with diseases. This surveyon population included a number of the haplotype frequencies in Khuzestan province. HLA allele recognition ishelpful in anthropological, transplantation and disease studies. Therefore, the aim of this study was investigatingthe association of HLA-DQA1*0102, -DQB1*0602, -DRB5*01 and -A*0301 haplotypes in normal populationaccording to Arab and Persian ethnicity.Methods: HLA-DQA1*0102, DQB1*0602, DRB5*01 and A*0301 genotypes were examined in Iranian normalpopulation of Khuzestan analyzing by polymerase chain reaction using specific sequence primers (PCR-SSP)method in 242 healthy blood donors without any disease. We studied the relationship of genotypes with ethnics.The statistical analyses were performed by SPSS software.Result: It was found that DQA1*0102+-DRB5*01- haplotype was associated with Persian ethnic compare withArabs (71% vs. 54.2%, p = 0.029, OR=0.481[95% CI =0.248-0.933]). However, it was not found any significantassociation between both Arab and Persian and following two allelic haplotypes: A*301- -DRB5*01- (58.13% vs65.9%, p =0.467, OR=0.720 [95% CI =0.297- 1.745]), DQB1*0602+-DRB5*01- (35.5% vs 46.6%, p=0.170,OR=0.632 [95% CI =0.328-1.220]). DQB1*0602+-A*301- (44.5 vs 50%, p=0.604, OR=0.800 [95% CI =0.344-1.860]).Conclusion: This study gives an insight into the HLA genetic pattern of normal population in Khuzestan province.It was shown that the DQA1*0102+-DRB5*01- haplotype has association with ethnicity in this population. AsKhuzestan is a high risk region for some diseases; thus, these findings encourage future research to investigate theinfluence of this haplotype in pathogenesis of the diseases.کلیدواژه ها
HLA-DQA1*0102; HLA-DQB1*0602, HLA-DRB5*01; HLA-A*0301; Haplotype; PCR-SSP; Iranمقالات مرتبط جدید
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