Nitric oxide synthase 2 polymorphisms increased the risk of Type 2 Diabetes in Zahedan, Southeastern Iran

  • سال انتشار: 1395
  • محل انتشار: اولین کنفرانس ملی یافته های نوین زیست شناسی
  • کد COI اختصاصی: BIOC01_080
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 352
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نویسندگان

Hamid Reza Galavi

student scientific research center,zahedan university of medical sciences,Zahedan ,Iran

Ramin Saravani

student scientific research center,zahedan university of medical ,sciences,Zahedan ,Iran

چکیده

In the present study we investigated the impact of Nitric oxide synthase 2 (NOS2) gene polymorphism on the susceptibility of type 2 diabetes (T2D) in a sample of Iranian population (Southeastern of Iran). Polymorphisms of the NOS2 rs2779248T/C and rs1137933C/T were determined in 152 T2D patients and 157 healthy controls (HC) by using T-ARMS PCR method.the finding showed that CT genotype of rs1137933C/T was significantly associated with increased risk of T2D (P< 0.0001) as well as the T allele of this single nucleotide polymorphism (SNP) was strong association with risk T2D (p< 0.0001). For rs2779248 T/C the results indicated that TC genotype of this SNP decrease risk of T2D (OR=0.25 95%CI= 0.15-0.42, P< 0.0001) however, CC genotype of this SNP increased risk of T2D (p< 0.005). There was no significant association between clinical-demographic characteristics of T2D group with both SNPS in dominant. our finding showed that The CT genotype and C allele of the NOS2 rs1137933 C/T polymorphism is associated with a higher risk for T2D, and there is no association between T allele of the NOS2 rs2779248 T/C polymorphism and T2D while TC genotype of this SNP decreased risk T2D in the study population

کلیدواژه ها

Diabetes Mellitus, Type 2, Polymorphism, Single Nucleotide, Nitric Oxide Synthase Type II

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