The role of long non coding rnas (lncrnas) in colorectal cancer.
- سال انتشار: 1396
- محل انتشار: سومین سمپوزیوم بین المللی سرطان نسترن
- کد COI اختصاصی: NASTARANCANSER03_285
- زبان مقاله: انگلیسی
- تعداد مشاهده: 436
نویسندگان
Institute Of Higher Education, ACECR, Isfahan Branch, Isfahan, Iran , Department Of Molecular And Cellular Biotechnology At Cell Science Research Center, Royan Institute For Biotechnology, ACECR, Isfahan, Iran
Department Of Molecular And Cellular Biotechnology At Cell Science Research Center, Royan Institute For Biotechnology, ACECR, Isfahan, Iran ;Department Of Biology, Shahrekord Branch, Islamic Azad University, Shahrekord, Iran
Department Of Molecular And Cellular Biotechnology At Cell Science Research Center, Royan Institute For Biotechnology, ACECR, Isfahan, Iran ;Department Of Biology, School Of Sciences, University Of Isfahan, Isfahan, Iran
Department Of Molecular And Cellular Biotechnology At Cell Science Research Center, Royan Institute For Biotechnology, ACECR, Isfahan, Iran
چکیده
Colorectal cancer is a major cause of cancer-related death worldwide .The development of colon cancer is a multifactorial and multi-stage process that abnormal expression of the gene plays an important role. With the advance of human tumor molecular biology, studies have highlighted the role of (lncRNAs) in the development of CRC. lncRNA is an RNA molecule, greater than 200 nt, which is not predicted to encode protein. lncRNAs have the Important roles in the regulation of gene expression at different levels epigenetic, transcriptional and post-transcriptional. At the epigenetic level:1) HOTAIR: The expression levels of HOTAIR and the prognosis of patients are positively correlated in CRC. HOTAIR promotes metastasis, recurrence and prognosis of CRC.2) MEG3: MEG3 expression is downregulated in CRC.3) PCAT-1: PCAT-1 expression in CRC tissues is significantly up- regulated.4) CCAT2: CCAT2 is highly overexpressed in CRC. At the transcription level :1) HULC: HULK is over-expressed in CRC and may be involved in the process of metastasis to the liver.2) Loc285194:This lncRNA functions as a potential tumor suppressor in CRC.3) H19:H19 promotes colorectal cancer metastasis and functions as a tumor oncogene via miR-148b and 200a.4) PTENP1: The 3’UTR of PTENP1 is a pseudogene of PTEN and Can be translated into the tumor suppressor protein PTEN. At the post-transcription level:1) CCAT:( CCAT1 - CCAT1-L - CCAT2 ) function as a tumor oncogene in CRC.2) MEG3: MEG3 is absent from the human colon cancer cell lines and functions as a Tumor suppressor.3) MALAT-1: Is overexpressed in CRC and functions as a tumor oncogene.کلیدواژه ها
Colorectal Cancer, Cancer Diagnosis, Cancer Prevention, Cell and Cancer, Cancer Treatment and Managementمقالات مرتبط جدید
- بازتاب دانش سنتی و باورهای عامیانه مربوط به محیط زیست در مثل ها و زبانزدهای بختیاری
- سرطان چگونه به وجود می آید؟
- آشنایی با انواع سرطان و علائم آنها، راه های تشخیص و درمان
- Deciphering the Impact of the L۸۵۸R Mutation in EGFR: Computational Insights and Therapeutic Implications in Non-Small-Cell Lung Cancer
- systematic review on Investigating the relationship between obesity and breast cancer in women
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.