Voltammetric determination of an anicancer drug in pharmaceutical formulation at different electrodes

سال انتشار: 1396
محل انتشار: چهارمین کنفرانس بین المللی پژوهشهای کاربردی در علوم شیمی و زیست شناسی
کد COI اختصاصی: CBGCONF04_179
زبان مقاله: انگلیسی
تعداد مشاهده: 595

نویسندگان

Department of Analytical Chemistry, Islamic Azad University Arak Branch, P.O.B: ۳۸۱۳۵۵۶۷, Arak, Iran

Department of Chemistry, Faculty of Science, Islamic Azad University,Omidiyeh Branch, P.O.B: ۶۳۷۳۱-۹۳۷۱۹, Omidiyeh, Iran

Mohammad Alimoradi

Department of Chemistry, Faculty of Science, Islamic Azad University, Arak Branch, P.O.B: ۳۸۱۳۵۵۶۷, Arak, Iran

چکیده

Tamoxifen (Tam) is an anticancer drug used in the treatment breast cancer. In this work, the electrochemical behavior of (Tam) were investigated by cyclic (CV) and differential-pulse anodic adsorptive striping (DPAAS) voltammetric techniques at different electrodes such as glassy carbon (GC), Au and Pt electrode in H2SO4 at different concentration. It was observed that at GCE electrocatalytic behavior for the oxidation of Tam was excellent. It was evidenced by the enhancement of oxidation peak current and shift in the oxidation potential to less positive values. Cyclic voltammetry (CV) and chronoamperometry were used to understand the electrochemical characteristics of Tam. Chronoamprograms gave a fundamental electrochemical parameter including the diffusion coefficient (D). Based on the results of the recorded CV, the electrodeposition and anodic striping behavior of the Tam were investigated at the surface of GCE. The primary experiments demonstrated that the DPAASV presents a sufficient oxidation peak current at approximately 1.03 V vs Ag/AgCl. Therefore, to find the best conditions for taking a sharp analytical peak concerning the electro-oxidation of Tam, the effects of different factors such as scan rate, deposition potential, deposition time and concentration of H2SO4 on anodic peak have been studied and optimized. A DPV method with good precision and accuracy was developed for the determination of Tam in pharmaceutical formulations. The calibration curve showed linearity in the range of 0.5 to 80 μM and the limits of detection (LOD) and quantitation (LOQ) were calculated to be 0.12 and 0.4 μM, respectively. The mean, standard error and relative standard deviation (RSD) for 4 replicates of 15 μM were found to be 15.57 μM, 3% and 4%, respectively.

کلیدواژه ها

Tamoxifen, DPAASV, Striping voltammetry, deposition

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.