Voltammetric sensor for determination of N-acetylcysteine based on electrochemical oxidation of 4,4' biphenol as a mediator
- سال انتشار: 1394
- محل انتشار: یازدهمین سمینار سالانه الکتروشیمی ایران
- کد COI اختصاصی: ELECTROCHEMISTRY011_321
- زبان مقاله: انگلیسی
- تعداد مشاهده: 474
نویسندگان
Phase Equilibria Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan
Phase Equilibria Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan
Phase Equilibria Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan
Phase Equilibria Research Laboratory, Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan
چکیده
The electro-catalytic oxidation of N-acetylcysteine has been studied in presence 4,4'-biphenol, using cyclic voltammetry as a diagnostic technique. Cyclic voltammetry (CV) technique was used to investigate thesuitability of incorporation of 4,4'-biphenol/4,4'-diphenoquinone redox as a mediator [1] for theelectrocatalytic oxidation of N-acetylcysteine in buffered aqueous solution(Phosphate buffer, pH:7). In this work, we described redox couple (4, 4'-biphenol and 4,4'-diphenoquinone) can be used as a suitable mediator for determination of N-acetylcysteine concentration based on the catalytic current (curve b in fig.1). The dependence of peak currents on pH, concentration and the potential scan rate was investigated. Under the optimum conditions the peak current was linear to the concentration of N-acetylcysteine in the range 50-500 in the cyclic voltammetry. The detection limits were determined as 8.3 M by CV method.The diffusion coefficient of N-acetylcysteine and the catalytic rate constant of the reaction of 4,4’-diphenoquinone with N-acetylcysteine based on an EC' mechanism, was estimated using digital simulation method by comparing the experimental cyclic voltammetric responses with the calculated results. [2-3] Finally, the electrocatalytic oxidation of N-acetylcysteine by 4, 4'-diphenoquinone can be employed as a new method for the voltammetric determination of N-acetylcysteine plasma samples.کلیدواژه ها
N-acetylcysteine, Catalytic current, 4, 4'-biphenol, Cyclic voltammetry, Digital simulation, EC' mechanismمقالات مرتبط جدید
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