A Novel nano Niosome Particles for Iron Chelation Drug delivery
- سال انتشار: 1393
- محل انتشار: پنجمین کنگره بین المللی نانو و فناوری نانو (ICNN2014)
- کد COI اختصاصی: ICNN05_755
- زبان مقاله: انگلیسی
- تعداد مشاهده: 930
نویسندگان
Department of Chemical Engineering, Tehran North Branch Islamic Azad University, Tehran, Iran
Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA, USA
epartmentof chemistry, Amir Kabir University, Tehran, Iran
Pilot Nano-biotechnology Department, Pasteur Institute of Iran, Tehran, Iran
چکیده
Deferoxamine has several drawbacks including swelling, itching,slow injection and pain.The Niosomeformulation is employed to prepare nanoparticles which are loaded by DFO. The nanoparticles are analysed for theirparticle size, Zeta potential, morphology and cytotoxicity effect on two cell lines and the results are compared withcommercial product as control. Nanoparticles have the average size of 115 nm and 136 nm and spherical morphologyand profile of release of formulated nanoparticles are more regulated and slower. Investigation of intracellular ironchelation ability analysis by iron overload simulation indicated that the inducing iron into cell and making artificial ironoverload in Hep-G2 cells and then treating with free DFO and formulated DFO. This Study provides new way forchanging the method of administration of DFOand reducing the dosage of drug and increasing the circulation time ofdrug.Plus, this study provides an efficient and novel targeting to organs like liver and heart.کلیدواژه ها
Nano-Niosome; Drug Delivery; Iron Chelation; Iron Overload; Deferoxamine (DFO)اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.