Elham Heydari - Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry, University of Mazandaran, Babolsar, Iran
Jahan-Bakhsh Raoof - Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry,University of Mazandaran, Babolsar, Iran
Zahra Bagheryan - Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry,University of Mazandaran, Babolsar, Iran
Reza Ojani - Eletroanalytical Chemistry Research Laboratory, Department of Analytical Chemistry, Faculty of Chemistry,University of Mazandaran, Babolsar, Iran

Cytosine-rich DNA sequences can form a highly ordered structure known as i-motif in slightly acidicsolutions. The stability of the folded i-motif structure is a good strategy to inhibit the telomerase reaction in cancer cells.Tamoxifen (Tam) is an antiestrogen hormonal agent for treatment of breast cancer for more than two decades. In thecurrent study, we designed an electrochemical biosensor by modifying a carbon paste electrode (CPE) with Sio2nanoparticle to investigate ligands which are able to interact with i-motif structure. The Tam drug was used as the modelligand and its ability for stabilizing i-motif structure was examined. The interaction between i-motif DNA and the drugTamoxifen (Tam), was studied in PBS buffer and [Fe (CN) 6]3- through the cyclic voltammetry (CV) and square wavevoltammetry (SWV) methods.

i-motif DNA, Tamoxifen, Anti-cancer, Electrochemical biosensor