Delayed Synaptic Changes in Axotomized Spinal Motoneurons of Newborn Rats Associated with Progressive Neuronal Loss: Immunohistochemical,Ultrastructural, and Quantitative Study
- سال انتشار: 1385
- محل انتشار: فصلنامه آسیب شناسی ایران، دوره: 1، شماره: 4
- کد COI اختصاصی: JR_IJP-1-4_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 608
نویسندگان
Department of Anatomy, School of Medicine, Shahed University, Tehran, Iran.
Department of Anatomy, School of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
چکیده
Background and Objective: Sciatic nerve transection is characterized by a rapid wave of motoneuron death associated with progressive synaptic lesions. The purpose of this study was to evaluatethe long term synaptic changes. Materials and Methods: This basic study was carried out on paraffin- or resin-embedded tissueblocks for evaluation of synaptophysin and choline acetyl transaferase (CHAT) immunoreactivities and the ultrastructural changes in the synapses of spinal motoneurons following sciatic nerve axotomy in the newborn rats. Results: The results showed that there was a progressive decrease in the percentage of survivedmotoneurons and high percentage of chromatolytic motoneurons. There was also a high percentageof degenerated motoneurons with dotted pattern synaptophysin immunoreactivity, low percentage of intact motoneurons with complete synaptophysin labeling, and high percentage of motoneurons withlow CHAT labeling. The ultrastructural study showed that there were many motoneurons with synapticpathological changes including irregularity of the synaptic membrane and displacement of synaptic vesicles. Conclusion: The findings of this study indicate that there is a delayed synaptic lesion in axotomized motoneurons of newborn ratsکلیدواژه ها
Motoneuron, Axotomy, Sciatic nerveمقالات مرتبط جدید
- Effect of Salicylic Acid and Root Inoculation with P. indica on Cd Phytoremediation Efficiency and Degradation of Soil Fuel Oil in the Salinity Stress
- Acute Effect of Concurrent Exercise on Serum Leptin and Resistance Insulin Response in Sedentary Men
- Analysis of Incidents Recorded Data of in Kashan Fire Department During ۱۹۹۹-۲۰۱۶
- Development and Psychometric of “Public Awareness on Emergency Response in the Workplace Questionnaire”
- تجزیه و تحلیل علل ریشه ای حوادث شغلی در صنایع به کمک تکنیک های مرسوم بررسی حوادث مطالعه موردی یک حادثه منجر به فوت در پست ۲۳۰ کیلوولت
اطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.