Effects of Vitex agnus and Flaxseed on cyclic mastalgia: A randomized controlled trial
- سال انتشار: 1402
- محل انتشار: اولین همایش ملی گیاهان داروئی تحقیق، توسعه و کاربرد در امور پزشکی و طب سنتی
- کد COI اختصاصی: MAPTCONF01_001
- زبان مقاله: انگلیسی
- تعداد مشاهده: 160
نویسندگان
Member of the academic faculty of Azad Islamic College, Maragheh branch, Maragheh
Member of the academic faculty of Azad Islamic College, Maragheh branch, Maragheh, Iran
Sakineh Mohammad-Alizadeh Charandabi
Associate Professor of Midwifery Group, Social Determinates of Health Research Center, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Iran
Associate Professor of Midwifery Group, Nursing and Midwifery Faculty, Tabriz University of Medical Sciences, Iran
Professor of Pharmaceutics, Medical Philosophy and History Research Center, Department of Traditional Pharmacy, Faculty of Traditional Medicine, Tabriz University of Medical Sciences, Tabriz, Iran
Member of the academic faculty of Azad Islamic College, Maragheh branch, Maragheh, Iran Iran
چکیده
Objectives: Evidence on the effect of Vitex agnus and Flaxseed on cyclical mastalgia is not enough. This study aimed to assess the efficacy of V. agnus and Flaxseed on cyclical mastalgia.Design and setting: This randomized controlled trial was conducted on ۱۵۹ women referred to health centers of Tabriz, Iran. Subjects were allocated into three groups (n=۵۳ per group) using block random-ization.Interventions and Main outcome measures: Group I received ۲۵g daily Flaxseed powder and placebo of V. agnus; group II received daily ۳.۲–۴.۸mg V. agnus tablet and placebo of Flaxseed and control group received both placebo. Nominal day breast pain was applied at baseline, first, and second month after the intervention. Data was analyzed using general linear model.Results: There was no statistical significant difference between the three groups in terms of socio-demographic characteristics and baseline values. The breast pain improved significantly in both intervention groups during the first and second month after intervention. Mean NDBP score was sig-nificantly lower than that in the control group at the first month after the intervention in the Flaxseed [adjusted mean difference: −۳.۱ (۹۵% CI: −۴.۲ to −۲.۰)] and V. agnus groups [−۳.۳ (−۴.۳ to −۲.۲)] and the second month after the intervention in Flaxseed [−۷.۰ (−۸.۱ to −۵.۹)] and V. agnus groups [−۶.۴ (−۷.۵ to −۵.۳)].Conclusion: Flaxseed and V. agnus are effective in short-term period in decreasing cyclical mastalgia. However, further studies are needed to examine the long-term effectiveness and sustainability of the effects after stopping the treatment in order to decide whether these alternative treatments are suitable to treat mastalgia or notکلیدواژه ها
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