Resveratrol Supplement Could Reverse the Effect of Resistance Training on Muscular eMHC and PAX۷ in BALB/C Mice Bearing CT-۲۶ Tumor
- سال انتشار: 1398
- محل انتشار: مجله گزارش بهداشت و درمان، دوره: 5، شماره: 4
- کد COI اختصاصی: JR_RHCA-5-4_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 61
نویسندگان
Department of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran
Department of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran
Department of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran
Department of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran
Department of Physical Education and Sport Sciences, Shiraz University, Shiraz, Iran
چکیده
Introduction: Although resistance training and resveratrol is recommended as a stimulant for muscle regeneration in healthy subjects their effects on cancer-related cachexia indices are unclear. This study aimed to investigate the effect of a course of resistance training with resveratrol supplement on PAX-۷ and eMHC in Gastrocnemius muscle tissue of mice bearing colon cancer induced cachexia. Methods: This was an experimental study conducted on ۲۰ six-week-old BALB/c mice implanted with CT-۲۶ tumor. The mice were randomly divided into four groups: resistance training, resveratrol, resveratrol with resistance training, and control. The resistance training group performed ۶ weeks of progressive resistance training, the resveratrol group received ۱۰۰ mg/kg resveratrol per day. ۴۸ hours after the last experimental session, the mice were sacrificed and PAX-۷ and eMHC protein levels were measured using ELISA test through specimen taken from gastrocnemius muscles. Statistical test of one way ANOVA was used for data analysis. Results: PAX-۷ level was significantly lower in resveratrol with resistance training group compared to control (P=۰.۰۰۹), resveratrol (P=۰.۰۰۵), and resistance training groups (P=۰.۰۰۲). eMHC was significantly lower in the resistance training group compared to the control (P=۰.۰۸), resistance training, and resveratrol groups (P=۰.۰۰۲). Conclusion: Resistance training was not an appropriate intervention for treating reduced muscular regeneration due to cachexia. However, regarding reducing effect of resveratrol supplementation with resistance training on PAX-۷ level, it may be recommended to improve muscular regeneration.کلیدواژه ها
Resistance Training, Resveratrol, PAX-۷, eMHC, Cancer, Cachexiaاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.