Evaluation of Thermal Properties of Ferromagnetic Core for Treatment of Solid Tumors by Electromagnetic Induction Hyperthermia
- سال انتشار: 1402
- محل انتشار: مجله فیزیک و مهندسی پزشکی، دوره: 13، شماره: 6
- کد COI اختصاصی: JR_JBPE-13-6_006
- زبان مقاله: انگلیسی
- تعداد مشاهده: 54
نویسندگان
Radiation Applications Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
Radiation Applications Research School, Nuclear Science and Technology Research Institute, Tehran, Iran
Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Energy Engineering, Sharif University of Technology, Tehran, Iran
Research Center for Science and Technology in Medicine, Tehran University of Medical Sciences, Tehran, Iran
Department of Biomedical Engineering, Amirkabir University of Technology, Tehran, Iran
چکیده
Background: Electromagnetic induction hyperthermia is a promising method to treat the deep-seated tumors such as brain and prostatic tumors. This technique is performed using the induction of electromagnetic waves in the ferromagnetic cores implanted at the solid tumor.Objective: This study aims at determining the conditions of the optimal thermal distribution in the different frequencies before performing the in vitro cellular study.Material and Methods: In this experimental study, the i-Cu alloy (۷۰.۴-۲۹.۶; wt%) was prepared and characterized and then the parameters, affecting the amount of induction heating in the ferromagnetic core, were investigated. Self-regulating cores in ۱, ۳, ۶, and ۹ arrangements in the water phantom with a volume of ۲ cm۳ were used as a replacement for solid tumor.Results: Inductively Coupled Plasma (ICP) analysis and Energy Dispersive X-ray Spectroscopy (EDS) show the uniformity of the alloy after ۴ times remeling by vacuum arc remelting furnace. The Vibrating Sample Magnetometer (VSM) shows that the Curie temperature (TC) of the ferromagnetic core is less than ۵۰ °C. Temperature profile with a frequency of ۱۰۰-۴۰۰ kHz for ۳۰ min, was extracted by infrared imaging camera, indicating the increase temperature in the range of ۴۲ °C to ۴۶ °C. Conclusion: The optimum conditions with used hyperthermia system are supplied in the frequency of ۱۰۰ kHz, ۲۰۰ kHz and ۴۰۰ kHz with ۶, ۳ and ۱ seeds, respectively. It is also possible to induce a temperature up to ۵۰ °C by increasing the number of seeds at a constant frequency and power, or by increasing the applied frequency at a constant number of seeds.کلیدواژه ها
Hyperthermia, Electromagnetic Fields, Ni-Cu Ferromagnetic Core, Solid Tumor, Water Phantom, Alloysاطلاعات بیشتر در مورد COI
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