Aqueous Cannabis Extract Prevents Induced by Ethylene Glycol-induced Renal Calcium Crystallization
- سال انتشار: 1397
- محل انتشار: مجله تحقیق در پزشکی مولکولی، دوره: 7، شماره: 1
- کد COI اختصاصی: JR_REMJ-7-1_002
- زبان مقاله: انگلیسی
- تعداد مشاهده: 63
نویسندگان
Department of Cardiovascular Surgery, Surgery and Trauma Research Group, Birjand University of Medical Sciences, Birjand, Iran.۹۷۱۷۸۵۳۵۷۷
Medical School, Shiraz University of Medical Sciences, Shiraz, Iran.
Birjand University of Medical Sciences, Birjand, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Birjand University of Medical Sciences, Birjand, Iran
Birjand University of Medical Sciences, Birjand, Iran
Cellular and Molecular Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Birjand University of Medical Sciences, Birjand, Iran.
Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI ۴۸۸۲۴, USA
چکیده
BACKGROUND: Some plant extracts can prevent kidney stone formation in a dose-dependent manner. In our study, we aimed to investigate the protective role of Cannabis sativa aqueous extraction on calcium oxalate formation in ethylene glycol-induced rats. MATERIALS AND METHODS: To evaluate anti-urolithiasis, variations of the main risk factors (citrate, phosphorous, calcium, and Ph) have been evaluated in ۲۴-hour urine samples of rats one day before the end of the experiment. Rats were divided into ۴ groups: group ۱ was administered regular drinking water; group ۲ was administered ۱% ethylene glycol in drinking water, group ۳ was administered ۱۰۰ mg/kg of Cannabis sativa extract for oral administration by gavage along with drinking water containing ۱% ethylene glycol; and group ۴ was administered ۲۰۰ mg/kg of Cannabis sativa extract by gavage along with drinking water containing ۱% ethylene glycol. Finally, histopathological slides from the kidney were also evaluated. RESULTS: Results showed that ۱۰۰ mg/kg and ۲۰۰ mg/kg doses of Cannabis sativa extract significantly reduced the mentioned risk factors in comparison with ethylene glycol-treated rats (p< ۰.۰۵). CONCLUSION: Histopathological slides showed reduced calcifications with extract treatment at ۲۰۰ mg/kg of Cannabis sativa. Thus, this antioxidant herb can prevent kidney stone formation. These findings pave the way for new therapy.کلیدواژه ها
Antioxidants, Cannabis sativa, Ethylene Glycol, Rats, Urate calcium oxalate stoneاطلاعات بیشتر در مورد COI
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