Saffron: New Option in Alzheimer’s Disease Treatment

سال انتشار: 1401
محل انتشار: اولین کنگره بین المللی مراقبت های تسکینی و حمایتی در سالمندان
کد COI اختصاصی: PSCE01_062
زبان مقاله: انگلیسی
تعداد مشاهده: 132

نویسندگان

Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran

Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran

چکیده

Introduction: Alzheimer's Disease (AD) is a neurodegenerative disorder associated with aging and the main etiology of dementia worldwide. Despite the immense research on this disease, only a few drugs capable of delay the progression of the disease are currently available. Saffron (Crocus sativus L.) has been commonly used as a medicinal plant, in food preparation and currently has vast therapeutic traits attributed to it.Material and methods: The strategy of the search was based on a focused literature review. Databases used to identify the most relevant articles included Google Scholar and PubMed. Search keywords used in variable forms included: “Alzheimer's Disease”, “crocetin”, “saffron”, “safranal” and “crocin”. Papers published in the last decade or related publications were chosen for this review article.Results: In vitro and in vivo preclinical studies have explained the efficacy of saffron on cognitive disturbance in animal models of AD, emphasizing that crocin seems to be capable of modifying Aβ and tau protein aggregation, decreasing oxidative stress and settting glutamate levels. Clinical studies have demonstrated that the impacts of saffron on cognitive impairment were not distinct from those produced by memantine and donepezil, also possessed a better safety profile.Conclusion: Saffron and its compounds should be further investigated due to consider them safer alternatives in AD treatment

کلیدواژه ها

Neurodegenerative disorders ،Alzheimer's Disease ،Saffro ،Crocin

مقالات مرتبط جدید

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.