Pectin-Reinforced Electrospun Nanofibers: Fabricationand Characterization of Highly Biocompatible Matsfor Wound Healing Applications
- سال انتشار: 1401
- محل انتشار: بیست و سومین کنگره بین المللی هیبریدی پزشکی تولید مثل و هجدهمین کنگره هیبریدی فناوری سلولهای بنیادی رویان
- کد COI اختصاصی: RROYAN23_256
- زبان مقاله: انگلیسی
- تعداد مشاهده: 129
نویسندگان
Department of Medical Biotechnology and Nanotechnology, Schoolof Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Department of Medical Biotechnology and Nanotechnology, Schoolof Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Department of Medical Biotechnology and Nanotechnology, Schoolof Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Department of Medical Biotechnology and Nanotechnology, Schoolof Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Department of Medical Biotechnology and Nanotechnology, Schoolof Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
Department of Medical Biotechnology and Nanotechnology, Schoolof Medicine, Mashhad University of Medical Sciences, Mashhad,Iran
چکیده
Objective: Utilizing naturally occurring subs tances for improvingthe biological properties of wound dressings is amongthe mos t promising s trategies in biomedicine.Materials and Methods: We here report the successful synthesisa series of electrospun nanofibers reinforced with naturalpolysaccharide pectin. The composition of the scaffolds wasdesigned as gelatin (GEL))-poly(ε-caprolactone) (PCL)/ poly(vinyl alcohol) (PVA))-Pectin.Results: The nanofibrous composites exhibited a smooth surfacewith fibers’ diameter ranging between ۳۱۵ and ۴۳۱ nm.The incorporation of pectin led to improvements in the nanofibrousscaffolds regarding hydrophilicity (۱۹° after ۵ sec), degradability(۴۱.۱۹۷ ± ۴.۲%), and water uptake (۲۴۱.۶۶۶ ± ۵۸.۹۲%). Moreover, in the term of mechanical properties, the highes t Young’s modulus (۲.۸ ± ۰.۶ MPa) related to c-PCL/Gel-PVA/Pec electrospun nanofibers compare to other nanofiber mats.From biological perspective, adding pectin to the polymericsubs trates resulted in enhanced antibacterial activity of the matsagains t both Gram-positive and Gram-negative species. On thispoint, the c-PVA/Pec mats could inhibit the growth of P. aeruginosaup to ۵۷.۱% in comparison to the control group. Wile, theinhibitory effect of c-PCL/GEL-PVA/Pec mats on S. aureus andP. aeruginosa were ۸.۴% and ۲۲.۶%, respectively. Furthermore,the PCL/GEL-PVA/Pec electrospun mats exhibited excellentblood and cell compatibility as well as could s timulate cell migrationin vitro.Conclusion: In conclusion, pectin can be easily mixed to biopolymersfor preparation of three-dimensional (۳D) electrospunnanofibers. Regarding their mechanical and biologicalperformance, electrospun composites can be potentially used aswound dressings; especially in cases where infectious woundmanagement is of great importance.کلیدواژه ها
Antibacterial Activity, Electrospun Nanofibers, NaturalPolymers, Pectin, Wound Healingمقالات مرتبط جدید
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