Qing Fei Hua Xian Decoction ameliorates bleomycin-induced pulmonary fibrosis by suppressing oxidative stress through balancing ACE-AngII-AT۱R/ACE۲-Ang-(۱-۷)-Mas axis
- سال انتشار: 1402
- محل انتشار: مجله علوم پایه پزشکی ایران، دوره: 26، شماره: 1
- کد COI اختصاصی: JR_IJBMS-26-1_014
- زبان مقاله: انگلیسی
- تعداد مشاهده: 223
نویسندگان
Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan ۴۳۰۰۷۱, Hubei, China
Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan ۴۳۰۰۷۱, Hubei, China
Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan ۴۳۰۰۷۱, Hubei, China
Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan ۴۳۰۰۷۱, Hubei, China
Department of Integrated Chinese and Western Medicine, Zhongnan Hospital of Wuhan University, Wuhan ۴۳۰۰۷۱, Hubei, China
چکیده
Objective(s): We aimed to investigate the preventative effect of Qing Fei Hua Xian Decoction (QFHXD) against pulmonary fibrosis (PF) and its potential mechanisms. Materials and Methods: Bleomycin (BLM)-induced rats were respectively treated with ۴۱۳.۳, ۸۲۶.۶, and ۱۲۳۹.۹ mg/kg of QFHXD and prednisone for ۲۸ days. The lung tissues of rats were collected on day ۲۸ for histological and western blotting analysis. Results: QFHXD significantly reduced alveolus inflammation, collagen accumulation, and fibrosis deposition in BLM-induced PF rats (P< ۰.۰۵). Collagen I and III, vimentin, and α-smooth muscle actin(α-SMA) expression levels were likewise decreased in PF rats treated with QFHXD (P< ۰.۰۵). Additionally, QFHXD increased the expression of nuclear factor erythroid ۲-related factor ۲ (Nrf۲) while decreasing NADPH oxidase ۴ (NOX۴) expression (P< ۰.۰۵). Furthermore, QFHXD suppressed the PF progression by down-regulating Angiotensin-Converting Enzyme (ACE) -Angiotensin II (AngII) -Angiotensin II Type ۱ Receptor (AT۱R) axis (P< ۰.۰۱) and up-regulating Angiotensin-Converting Enzyme ۲ (ACE۲) -Angiotensin-(۱-۷) (Ang-(۱-۷)) -Mas axis (P< ۰.۰۵). Conclusion: QFHXD suppressed inflammatory infiltration and PF brought on by BLM in lung tissues through reducing oxidative stress by maintaining the equilibrium of ACE-AngII-AT۱R and ACE۲-Ang-(۱-۷) -Mas axes. This study may provide a novel clinical therapy option for PF.کلیدواژه ها
Extracellular matrix, Lung Diseases, NADPH oxidases, Oxidative stress, Pulmonary Fibrosis, Renin-angiotensin systemاطلاعات بیشتر در مورد COI
COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.
کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.