Resistin and prooxidant-antioxidant balance: Markers to discriminate acute coronary syndrome from stable angina

  • سال انتشار: 1399
  • محل انتشار: مجله آریا آترواسکلروز، دوره: 16، شماره: 2
  • کد COI اختصاصی: JR_RYA-16-2_001
  • زبان مقاله: انگلیسی
  • تعداد مشاهده: 283
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نویسندگان

Ali Pourmoghaddas

Interventional Cardiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Armin Elahifar

Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Faramarz Darabi

Heart Failure Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Ahmad Movahedian

Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences AND Isfahan Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

Afshin Amirpour

Assistant Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Nizal Sarrafzadegan

۲- Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran ۶- Faculty of Medicine, School of Population and Public Health, University of British Columbia, Vancouver,

چکیده

BACKGROUND: Resistin and oxidative stress may play a role in the pathogenesis of coronary heart disease (CHD) including acute coronary syndrome (ACS). The aim of this study was to investigate the role of serum resistin and prooxidant-antioxidant balance (PAB) in ACS occurrence in order to differentiate it from stable angina. Moreover, we aimed to determine the correlation between resistin and PAB in patients with ACS and its difference from patients with stable CHD.METHODS: This cross-sectional, descriptive study was conducted on ۵۰ patients with ACS and ۵۰ patients with stable CHD who underwent coronary angiography (CAG). Serum resistin level was measured using enzyme-linked immunosorbent assay (ELISA). PAB and other variables were analyzed using standard methods.RESULTS: A significant increase in serum resistin and PAB was observed in patients with ACS (۲.۵۵ ± ۰.۱۳ ng/ml and ۱۲۳.۵ ± ۵.۵۸ HK unit, respectively) compared to patients with stable CHD (۱.۵۳ ± ۰.۱۲ ng/ml and ۹۵.۹ ± ۲.۷ HK unit, respectively) (P < ۰.۰۰۱). In addition, a significant positive correlation was seen between serum resistin and PAB in patients with ACS (r = ۰.۳۹; P = ۰.۰۰۵), but this correlation was not found in patients with stable CHD (r = ۰.۲۱; P = ۰.۱۴۰). Resistin (r = ۰.۵۲; P < ۰.۰۰۱) and PAB (r = ۰.۵۵; P < ۰.۰۰۱) were significantly associated with high-sensitivity C-reactive protein (hs-CRP) in patients with ACS, but this association was not found in patients with stable CHD (resistin: r = ۰.۲۴; P = ۰.۰۹۰; PAB: r = -۰.۰۲: P = ۰.۹۱۰).CONCLUSION: High serum resistin or PAB levels, and their association with the occurrence of ACS, can be used as a robust discriminating factor to differentiate ACS from stable CHD. 

کلیدواژه ها

Acute Coronary Syndrome, Resistin, Antioxidants

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