Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives
- سال انتشار: 1401
- محل انتشار: فصلنامه تحقیقات جاری در داروسازی، دوره: 8، شماره: 2
- کد COI اختصاصی: JR_TIPS-8-2_004
- زبان مقاله: انگلیسی
- تعداد مشاهده: 168
نویسندگان
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Biotechnology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Pharmaceutical Sciences Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Medicinal Chemistry, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
چکیده
In recent years, resistance to conventional antimicrobial drugs has become a serious concern in the clinic. Hence, the discovery of novel and effective antimicrobial agents with improved properties is of great value. In this study, the antibacterial and anticandidal activities of some imidazole, benzimidazole and benztriazole derivatives (C۱-C۸) against several species of Gram-positive and Gram-negative bacteria, including Staphylococcus aureus, Streptococcus pyogenes, Escherichia coli and Salmonella typhi as well as one species of fungi including Candida albicans, were evaluated using Clinical & Laboratory Standards Institute (CLSI) method. Antimicrobial evaluation revealed that among the tested compounds, imidazole derivative (C۵) indicated the highest activity against bacterial strains and Candida albicans. It was found that compound C۵ is more potent than ampicillin against S. aureus strain (MIC =۲-۱۶ µg/mL) and possessed excellent anticandidal activity (MIC =۱ µg/mL) which was comparable to Amphotericin B as the positive control. In addition, cytotoxic activity of the tested compounds was investigated using MTT assay. The results of MTT assay demonstrated that the toxicity of the tested compounds was less than ۳۵%. Please cite this article as: Sara Sadeghian, Ahmad Gholami, Soghra Khabnadideh, Razieh Razmi, Issa Sadeghain, Younes Ghasemi & Zahra Rezaei. Evaluation of Antibacterial and Anticandidal Activities of Some Imidazole, Benzimidazole and Benztriazole Derivatives. Trends in Pharmaceutical Sciences. ۲۰۲۲;۸(۲):۷۵-۸۴ .doi: ۱۰.۳۰۴۷۶/TIPS.۲۰۲۲.۹۳۶۳۷.۱۱۲۶کلیدواژه ها
Azoles, Antimicrobial effect, Antifungal Activity, MTTاطلاعات بیشتر در مورد COI
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