Environmental factors affecting the risk of breast cancer and the modulating role of vitamin D on this malignancy

سال انتشار: 1400
محل انتشار: مجله علوم محیط زیستی و نوآوری تکنولوژی آسیای مرکزی، دوره: 2، شماره: 4
کد COI اختصاصی: JR_CAS-2-4_004
زبان مقاله: انگلیسی
تعداد مشاهده: 188

نویسندگان

Basaksehir Cam and Sakura City Hospital, Department of Gynecology and Obstetrics, University of Health Science, Istanbul, Turkey

Danial Kahrizi

Nanobiotechnology Department, Faculty of Innovative Science and Technology, Razi University, Kermanshah, Iran

Zahra Aziziaram

Research and Development Department, Giga Biotics, San Diego, California, USA

چکیده

The term cancer is derived from the Greek word crab. The ancient Greek physician Hippocrates likened diffuse cancer to a crab. Although our understanding of the disease has improved since then, this explanation still seems appropriate. Breast cancer is the most common type of cancer in women worldwide and is the second leading cause of cancer-related death in women after lung cancer. The disease is affected by factors such as the genetic structure of hormonal profiles and different lifestyles. Geographical status, living status, age of marriage, obesity, and nutritional factors are among the environmental factors predisposing to breast cancer. Among dietary supplements, the protective effect of vitamin D on breast cancer has been confirmed. The inverse relationship between sun exposure and breast cancer mortality has been proven. The direct link between decreased serum vitamin D and an increased risk of breast cancer has also been confirmed. In some breast cancer cells, the active form of vitamin D increases the expression of adhesion molecules, which prevents cancer from invasion and metastasis. In addition, this active form has anti-angiogenic activity and can inhibit cancer cell invasion. In this review, we narrate the environmental factors affecting the risk of breast cancer and the modulating role of vitamin D in this malignancy.

کلیدواژه ها

breast cancer, Environmental Factors, Vitamin D, Vitamin D receptor, Genomic pathway, Non-genomic pathway

اطلاعات بیشتر در مورد COI

COI مخفف عبارت CIVILICA Object Identifier به معنی شناسه سیویلیکا برای اسناد است. COI کدی است که مطابق محل انتشار، به مقالات کنفرانسها و ژورنالهای داخل کشور به هنگام نمایه سازی بر روی پایگاه استنادی سیویلیکا اختصاص می یابد.

کد COI به مفهوم کد ملی اسناد نمایه شده در سیویلیکا است و کدی یکتا و ثابت است و به همین دلیل همواره قابلیت استناد و پیگیری دارد.