In vitro anticancer activity of methanolic extract of Chroococcus sp., from Kani Barazan International Wetland
- سال انتشار: 1400
- محل انتشار: سومین کنگره بین المللی و چهارمین همایش ملی زیست فناوری گیاهان دارویی و قارچهای کوهی (مجازی)
- کد COI اختصاصی: BMPM04_043
- زبان مقاله: انگلیسی
- تعداد مشاهده: 276
نویسندگان
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.Department of Plant Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.Liver and Gastrointestinal Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Research Center for Pharmaceutical Nanotechnology, Biomedicine Institute, Tabriz University of Medical Sciences, Tabriz, Iran.Connective Tissue Diseases Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Plant Biology, Faculty of Natural Science, University of Tabriz, Tabriz, Iran.
College of Pharmacy, Nova Southeastern University, Fort Lauderdale, FL, USA.
چکیده
The current bioprospecting study has been conducted to develop the new anticancer agents with higher efficiency of microalgae isolated from the Kani Barazan International Wetland in the south of Lake Urmia. Microalgae as one of the large and diverse groups of autotrophic organisms are able to use in different biomedical sources due to their antioxidant and anticancer properties. In this study, biological impacts (DPPH radical scavenging, MTT assay, Annexin VP/I, and cell cycle) of methanolic extract (ME) from Chroococcus turgidusa were evaluated against colorectal and gastric cancer cells. Based on our result, the ME can significantly inhibit cell proliferation and induce apoptosis in SW۴۸۰ and AGS cell lines. Conclusively, the ME of Ch. turgidusa can be presented as a potential preventive/therapeutic agent in gastrointestinal cancers. To the best of our knowledge there is no scientific published data about Ch. turgidusa anticancer effects.کلیدواژه ها
Anticancer activity, Antioxidant capacity, Apoptosis, Chroococcus turgidusa, Methanolic extractمقالات مرتبط جدید
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